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1.C.18.1.1
Melittin major precursor (anion selective).  Its bacteriocidal activity against Listeria and its cytotoxicity to animal cells have been studied (Wu et al. 2016).

Accession Number:P01501
Protein Name:MEL aka MELT
Length:70
Molecular Weight:7585.00
Species:Apis mellifera (Honeybee), and Apis cerana (Indian honeybee) [7460]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

RefSeq: NP_001011607.1   
Entrez Gene ID: 406130   
Pfam: PF01372   
KEGG: ame:406130   

Gene Ontology

GO:0005576 C:extracellular region
GO:0046930 C:pore complex
GO:0004860 F:protein kinase inhibitor activity
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0006811 P:ion transport
GO:0009405 P:pathogenesis

References (7)

[1] “Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin.”  Vlasak R.et.al.   6309516
[2] “Sequence analysis of melittin from tryptic and peptic degradation products.”  Habermann E.et.al.   5592400
[3] “Haemolytic activity and action on the surface tension of aqueous solutions of synthetic melittins and their derivatives.”  Schroeder E.et.al.   5139482
[4] “Isolation and structure of N 1-formyl melittin.”  Luebke K.et.al.   5139483
[5] “Isolation and structures of grammistins, peptide toxins from the skin secretion of the soapfish Grammistes sexlineatus.”  Shiomi K.et.al.   10669014
[6] “The structure of melittin. II. Interpretation of the structure.”  Terwilliger T.C.et.al.   7076662
[7] “The actions of melittin on membranes.”  Dempsey C.E.et.al.   2187536
Structure:
1BH1   2MLT   2MW6   3QRX     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFLVNVALV FMVVYISYIY AAPEPEPAPE PEAEADAEAD PEAGIGAVLK VLTTGLPALI 
61:	SWIKRKRQQG