TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.19.1.3
Neutrophil cationic peptide-1 precursor (permeable to Cl-, Na+ and K+)

Accession Number:P11478
Protein Name:DEF1
Length:93
Molecular Weight:10479.00
Species:Cavia porcellus (Guinea pig) [10141]
Location1 / Topology2 / Orientation3: Secreted1
Substrate Cl-, Na+, K+

Cross database links:

Pfam: PF00323    PF00879   

Gene Ontology

GO:0005615 C:extracellular space
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0031640 P:killing of cells of another organism
GO:0009615 P:response to virus

References (4)

[1] “Characterization of cDNA clones encoding guinea pig neutrophil cationic peptides.”  Nagaoka I.et.al.   2013325
[2] “Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin.”  Selsted M.E.et.al.   3623703
[3] “Isolation and characterization of corticostatic peptides from guinea pig bone marrow.”  Hu J.et.al.   1659400
[4] “Purification, primary structure, and biological activity of guinea pig neutrophil cationic peptides.”  Yamashita T.et.al.   2473036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRTVPLFAAC LLLTLMAQAE PLPRAADHSD TKMKGDREDH VAVISFWEEE STSLEDAGAG 
61:	AGRRCICTTR TCRFPYRRLG TCIFQNRVYT FCC