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1.C.19.1.5
Defensin-related cryptdin-4 precursor, Crp4 (structure: 2GW9_A) (Cummings and Vanderlick, 2007).

Accession Number:P28311
Protein Name:Crp4
Length:92
Molecular Weight:10272.00
Species:Mus musculus (Mouse) [10090]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

Genevestigator: P28311
eggNOG: roNOG17814
RefSeq: NP_034169.1   
Entrez Gene ID: 13238   
Pfam: PF00879   
KEGG: mmu:13238   

Gene Ontology

GO:0005615 C:extracellular space
GO:0005543 F:phospholipid binding
GO:0042742 P:defense response to bacterium

References (6)

[1] “Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse Paneth cell alpha-defensin.”  Ouellette A.J.et.al.   10569786
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.”  Ouellette A.J.et.al.   7927786
[4] “Structure and diversity of the murine cryptdin gene family.”  Huttner K.M.et.al.   8188287
[5] “Enteric defensins: antibiotic peptide components of intestinal host defense.”  Selsted M.E.et.al.   1500431
[6] “Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin.”  Jing W.et.al.   15595831
Structure:
1TV0   2GW9   2GWP   2LEW   2LEY     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTLVLLSAL VLLAFQVQAD PIQNTDEETK TEEQPGEEDQ AVSISFGGQE GSALHEKSLR 
61:	GLLCYCRKGH CKRGERVRGT CGIRFLYCCP RR