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1.C.19.1.6
Theta defensin 1a precursor, RTD1a (Tran et al., 2008)

Accession Number:P82270
Protein Name:RTD1
Length:76
Molecular Weight:8242.00
Species:Macaca mulatta (Rhesus macaque) [9544]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate small molecules, electrolytes, water

Cross database links:

RefSeq: NP_001027989.1   
Entrez Gene ID: 574122   
Pfam: PF00879   
KEGG: mcc:574122   

Gene Ontology

GO:0005615 C:extracellular space
GO:0050832 P:defense response to fungus
GO:0050829 P:defense response to Gram-negative bacterium
GO:0050830 P:defense response to Gram-positive bacterium
GO:0031640 P:killing of cells of another organism

References (3)

[1] “A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins.”  Tang Y.-Q.et.al.   10521339
[2] “Circular minidefensins and posttranslational generation of molecular diversity.”  Leonova L.et.al.   11527997
[3] “Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides.”  Tran D.et.al.   11675394

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MRTFALLTAM LLLVALHAQA EARQARADEA AAQQQPGTDD QGMAHSFTWP ENAALPLSES 
61:	AKGLRCICTR GFCRLL