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1.C.20.1.1
Class I lantibiotic bacteriocin Nisin precursor (has a mersacidin-like Lipid II domain, and forms Lipid II-dependent pores) (Brötz et al., 1998). Its activity is enhanced by the SlpB surface layer protein (Q09FL7) of Lactobacillus crispatus (Sun et al. 2017).

Accession Number:P13068
Protein Name:LANN aka SPAN aka NISA
Length:57
Molecular Weight:5963.00
Species:Lactococcus lactis (subsp [1360]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF02052   

Gene Ontology

GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050830 P:defense response to Gram-positive bacterium

References (10)

[1] “Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic.”  Buchman G.W.et.al.   3141403
[2] “Characterization of the nisin gene as part of a polycistronic operon in the chromosome of Lactococcus lactis ATCC 11454.”  Steen M.T.et.al.   1905517
[3] “Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product.”  Kaletta C.et.al.   2493449
[4] “Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein.”  Engelke G.et.al.   1482192
[5] “Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.”  Kuipers O.P.et.al.   7689965
[6] “The structure of nisin.”  Gross E.et.al.   5131162
[7] “NMR studies of lantibiotics. The structure of nisin in aqueous solution.”  van de Ven F.J.et.al.   1765078
[8] “Solution structures of nisin A and its two major degradation products determined by NMR.”  Lian L.-Y.et.al.   1575686
[9] “NMR and circular dichroism studies of the lantibiotic nisin in non-aqueous environments.”  van den Hooven H.W.et.al.   8454055
[10] “15N- and 13C-labeled media from Anabaena sp. for universal isotopic labeling of bacteriocins: NMR resonance assignments of leucocin A from Leuconostoc gelidum and nisin A from Lactococcus lactis.”  Sailer M.et.al.   8418850

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FASTA formatted sequence
1:	MSTKDFNLDL VSVSKKDSGA SPRITSISLC TPGCKTGALM GCNMKTATCH CSIHVSK