TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family

Class I lantibiotic bacteriocin Nisin precursor (has a mersacidin-like Lipid II domain, and forms Lipid II-dependent pores) (Brötz et al., 1998). Its activity is enhanced by the SlpB surface layer protein (Q09FL7) of Lactobacillus crispatus (Sun et al. 2017).

Accession Number:P13068
Protein Name:LANN aka SPAN aka NISA
Molecular Weight:5963.00
Species:Lactococcus lactis (subsp [1360]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF02052   

Gene Ontology

GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050830 P:defense response to Gram-positive bacterium

References (10)

[1] “Structure, expression, and evolution of a gene encoding the precursor of nisin, a small protein antibiotic.”  Buchman   3141403
[2] “Characterization of the nisin gene as part of a polycistronic operon in the chromosome of Lactococcus lactis ATCC 11454.”  Steen   1905517
[3] “Nisin, a peptide antibiotic: cloning and sequencing of the nisA gene and posttranslational processing of its peptide product.”  Kaletta   2493449
[4] “Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein.”  Engelke   1482192
[5] “Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity.”  Kuipers   7689965
[6] “The structure of nisin.”  Gross   5131162
[7] “NMR studies of lantibiotics. The structure of nisin in aqueous solution.”  van de Ven   1765078
[8] “Solution structures of nisin A and its two major degradation products determined by NMR.”  Lian   1575686
[9] “NMR and circular dichroism studies of the lantibiotic nisin in non-aqueous environments.”  van den Hooven   8454055
[10] “15N- and 13C-labeled media from Anabaena sp. for universal isotopic labeling of bacteriocins: NMR resonance assignments of leucocin A from Leuconostoc gelidum and nisin A from Lactococcus lactis.”  Sailer   8418850

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)


Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence