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1.C.20.1.5
Class I lantibiotic bacteriocin, Subtilin precursor

Accession Number:P10946
Protein Name:LANS aka SPAS aka SUB
Length:56
Molecular Weight:6218.00
Species:Bacillus subtilis [1423]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

Pfam: PF02052   

Gene Ontology

GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050830 P:defense response to Gram-positive bacterium

References (10)

[1] “Structure and expression of a gene encoding the precursor of subtilin, a small protein antibiotic.”  Banerjee S.et.al.   2837490
[2] “The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein.”  Chung Y.J.et.al.   1735728
[3] “Analysis of genes involved in biosynthesis of the lantibiotic subtilin.”  Klein C.et.al.   1539969
[4] “Determination of the sequence of spaE and identification of a promoter in the subtilin (spa) operon in Bacillus subtilis.”  Chung Y.J.et.al.   1400221
[5] “Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633.”  Klein C.et.al.   8085823
[6] “Subtilin, VI: the structure of subtilin.”  Gross E.et.al.   4154277
[7] “The peptide antibiotic subtilin acts by formation of voltage-dependent multi-state pores in bacterial and artificial membranes.”  Schueller F.et.al.   2471644
[8] “A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633.”  Chan W.C.et.al.   8471040
[9] “Sequence-specific resonance assignment and conformational analysis of subtilin by 2D NMR.”  Chan W.C.et.al.   1547888
[10] “The antimicrobial effect of a structural variant of subtilin against outgrowing Bacillus cereus T spores and vegetative cells occurs by different mechanisms.”  Liu W.et.al.   8434932

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSKFDDFDLD VVKVSKQDSK ITPQWKSESL CTPGCVTGAL QTCFLQTLTC NCKISK