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1.C.20.1.8
Mutacin 1140 precursor (homologous to several lantibiotics but does not form pores (Smith et al., 2008))

Accession Number:O68586
Protein Name:Mutacin 1140
Length:63
Molecular Weight:6968.00
Species:Streptococcus mutans [1309]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

Pfam: PF02052   

Gene Ontology

GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0050830 P:defense response to Gram-positive bacterium

References (3)

[1] “Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans.”  Hillman J.D.et.al.   9596742
[2] “Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.”  Qi F.et.al.   10473390
[3] “Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics.”  Smith L.et.al.   11082191

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNTQLLEVL GTETFDVQED LFAFDTTDTT IVASNDDPDT RFKSWSLCTP GCARTGSFNS 
61:	YCC