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1.C.21.1.5
Nukacin ISK-1 of 57 aas (Okuda et al., 2008). It is active on Gram-positive bacteria, including Lactobacillus sakei, Leuconostoc mesenteroides and Pediococcus pentosaceus. The bactericidal activity is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (Aso et al. 2004). It is processed and secreted by NukT (TC# 3.A.1.111.7) (Zheng et al. 2017).

Accession Number:Q9KWM4
Protein Name:ISK-1 aka NukA
Length:57
Molecular Weight:6403.00
Species:Staphylococcus warneri [1292]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

RefSeq: NP_940772.1   
Entrez Gene ID: 2648465   
Pfam: PF04604   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium
GO:0019748 P:secondary metabolic process

References (5)

[1] “A novel lantibiotic, nukacin ISK-1, of Staphylococcus warneri ISK-1: cloning of the structural gene and identification of the structure.”  Sashihara T.et.al.   11193411
[2] “Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.”  Aso Y.et.al.   15322349
[3] “Description of complete DNA sequence of two plasmids from the nukacin ISK-1 producer, Staphylococcus warneri ISK-1.”  Aso Y.et.al.   15737403
[4] “Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.”  Aso Y.et.al.   16233732
[5] “Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1.”  Asaduzzaman S.M.et.al.   16957223

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FASTA formatted sequence
1:	MENSKVMKDI EVANLLEEVQ EDELNEVLGA KKKSGVIPTV SHDCHMNSFQ FVFTCCS