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1.C.21.1.5
Nukacin ISK-1 (Okuda et al., 2008)

Accession Number:Q9KWM4
Protein Name:ISK-1 aka NukA
Length:57
Molecular Weight:6403.00
Species:Staphylococcus warneri [1292]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

RefSeq: NP_940772.1   
Entrez Gene ID: 2648465   
Pfam: PF04604   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium
GO:0019748 P:secondary metabolic process

References (5)

[1] “A novel lantibiotic, nukacin ISK-1, of Staphylococcus warneri ISK-1: cloning of the structural gene and identification of the structure.”  Sashihara T.et.al.   11193411
[2] “Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.”  Aso Y.et.al.   15322349
[3] “Description of complete DNA sequence of two plasmids from the nukacin ISK-1 producer, Staphylococcus warneri ISK-1.”  Aso Y.et.al.   15737403
[4] “Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.”  Aso Y.et.al.   16233732
[5] “Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1.”  Asaduzzaman S.M.et.al.   16957223

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENSKVMKDI EVANLLEEVQ EDELNEVLGA KKKSGVIPTV SHDCHMNSFQ FVFTCCS