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1.C.26.1.1
Class IIb two peptide bacteriocin Lactacin F (LafA)-Lactacin X (LafX)

Accession Number:P24022
Protein Name:LafA aka LAF
Length:75
Molecular Weight:7604.00
Species:Lactobacillus johnsonii [33959]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules, electrolytes, water

Cross database links:

HEGENOM: HBG698342
RefSeq: NP_964622.1   
Entrez Gene ID: 2743693   
Pfam: PF10439   
BioCyc: LJOH257314:LJ_0769-MONOMER   
KEGG: ljo:LJ0769   

Gene Ontology

GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium

References (4)

[1] “Cloning, phenotypic expression, and DNA sequence of the gene for lactacin F, an antimicrobial peptide produced by Lactobacillus spp.”  Muriana P.M.et.al.   1900281
[2] “Molecular analysis of the lactacin F operon.”  Fremaux C.et.al.   8285694
[3] “The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533.”  Pridmore R.D.et.al.   14983040
[4] “Purification and partial characterization of lactacin F, a bacteriocin produced by Lactobacillus acidophilus 11088.”  Muriana P.M.et.al.   1903624

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKQFNYLSHK DLAVVVGGRN NWQTNVGGAV GSAMIGATVG GTICGPACAV AGAHYLPILW 
61:	TAVTAATGGF GKIRK