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1.C.3.2.4
Necrotic enteritis toxin B precursor, NetB (Keyburn et al., 2008)

Accession Number:A8ULG6
Protein Name:NetB
Length:322
Molecular Weight:36461.00
Species:Clostridium perfringens [1502]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF07968   

Gene Ontology

GO:0005576 C:extracellular region
GO:0051715 P:cytolysis of cells of another organism
GO:0009405 P:pathogenesis

References (2)

[1] “NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens.”  Keyburn A.L.et.al.   18266469
[2] “In vitro production of necrotic enteritis toxin B, NetB, by netB-positive and netB-negative Clostridium perfringens originating from healthy and diseased broiler chickens.”  Abildgaard L.et.al.   20092968
Structure:
4H56   4I0N     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRLKIISIT LVLTSVISTS LFSTQTQVFA SELNDINKIE LKNLSGEIIK ENGKEAIKYT 
61:	SSDTASHKGW KATLSGTFIE DPHSDKKTAL LNLEGFIPSD KQIFGSKYYG KMKWPETYRI 
121:	NVKSADVNNN IKIANSIPKN TIDKKDVSNS IGYSIGGNIS VEGKTAGAGI NASYNVQNTI 
181:	SYEQPDFRTI QRKDDANLAS WDIKFVETKD GYNIDSYHAI YGNQLFMKSR LYNNGDKNFT 
241:	DDRDLSTLIS GGFSPNMALA LTAPKNAKES VIIVEYQRFD NDYILNWETT QWRGTNKLSS 
301:	TSEYNEFMFK INWQDHKIEY YL