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1.C.3.4.1
Leucocidin chain F.  3-D structures of the prepore reveal that this is substantially different from the pore structure.  The structures revealed a disordered bottom half of the beta-barrel corresponding to the transmembrane region, and a rigid upper extramembrane half (Yamashita et al. 2014).  Panton-Valentine leukocidin (PVL, encoded by lukSF-PV genes) is a bi-component and pore-forming toxin carried by different staphylococcal bacteriophages (Zhao et al. 2016).

Accession Number:Q53747
Protein Name:LukF
Length:325
Molecular Weight:37009.00
Species:Staphylococcus aureus [1280]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF07968   

Gene Ontology

GO:0005576 C:extracellular region
GO:0051715 P:cytolysis of cells of another organism
GO:0009405 P:pathogenesis

References (1)

[1] “Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities.”  Prevost G.et.al.   7558328

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKIVKSREV TSIALLLLSN TLDAAQHITP VSEKKVDDKI TLYKTTATSD SDKLKISQIL 
61:	TFNFIKDKSY DKDTLILKAA GNIYSGYTKP NPKDTISSQF YWGSKYNISI NSDSNDSVNV 
121:	VDYAPKNQNE EFQVQQTVGY SYGGDINISN GLSGGGNGSK SFSETINYKQ ESYRTSLDKR 
181:	TNFKKIGWDV EAHKIMNNGW GPYGRDSYHS TYGNEMFLGS RQSNLNAGQN FLEYHKMPVL 
241:	SRGNFNPEFI GVLSRKQNAA KKSKITVTYQ SEMDRYTNFW INFNWIGNNY KDHIRATHTS 
301:	IYEVDWENHT VKLIDTQSKE KNPMS