TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.3.4.3
Two component β-barrel γ-haemolysin, HlgC·HlgB. HglC is identical to Leucocidin chain S (LukS) (P31716), and HlgB is identical to the HlgB protein listed under TC# 1.C.3.4.2 (Roblin et al. 2008).

Accession Number:Q07227
Protein Name:Gamma-hemolysin component C aka HlgC
Length:315
Molecular Weight:35614.00
Species:Staphylococcus aureus [1280]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate small molecules

Cross database links:

Pfam: PF07968   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (2)

[1] “The gamma-hemolysin locus of Staphylococcus aureus comprises three linked genes, two of which are identical to the genes for the F and S components of leukocidin.”  Cooney J.C.et.al.   8423103
[2] “Molecular cloning and genetic analysis of the determinant for gamma-lysin, a two-component toxin of Staphylococcus aureus.”  Cooney J.C.et.al.   3075655

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLKNKILTTT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED KTSNKWGVTQ 
61:	NIQFDFVKDK KYNKDALILK MQGFISSRTT YYNYKKTNHV KAMRWPFQYN IGLKTNDKYV 
121:	SLINYLPKNK IESTNVSQTL GYNIGGNFQS APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ 
181:	NSKSVLWGVK ANSFATESGQ KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS 
241:	FIATVSHEKG SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY 
301:	EVNWKTHEIK VKGQN