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1.C.33.1.10
The LL-37 peptide (selectively permeabilizes the membranes of apoptotic human leukocytes, leaving viable cells unaffected (Björstad et al., 2009). It forms transmembrane pores (Lee et al., 2011).  It is derived by proteolysis from the cathelin (FALL-39) precursor in granulocytes (Gudmundsson et al. 1996; Li et al. 2016).

Accession Number:P49913
Protein Name:Cathelicidin antimicrobial peptide
Length:170
Molecular Weight:19301.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P49913
eggNOG: prNOG07162
HEGENOM: HBG127142
RefSeq: NP_004336.2   
Entrez Gene ID: 820   
Pfam: PF00666   
OMIM: 600474  gene
KEGG: hsa:820   

Gene Ontology

GO:0005576 C:extracellular region

References (9)

[1] “FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.”  Agerberth B.et.al.   7529412
[2] “hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules.”  Cowland J.B.et.al.   7615076
[3] “Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.”  Larrick J.W.et.al.   7890387
[4] “Structural, functional analysis and localization of the human CAP18 gene.”  Larrick J.W.et.al.   8946956
[5] “The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.”  Gudmundsson G.H.et.al.   8681941
[6] “Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules.”  Bals R.et.al.   11238224
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.”  Li X.et.al.   16637646
[9] “Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.”  Wang G.et.al.   18818205
Structure:
2FBS   2FBU   2FCG   2K6O   2LMF   4EYC     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD 
61:	LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS 
121:	FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES