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1.C.33.1.2
PreIndolicidin (pre-Cathelicidin-4). May function by a carrier mechanism to selectively transport anions (Rokitskaya et al., 2011).  The pig (ovine) homologue (SMAP29) is the source from which ovispirin, novispirin and novicidin, which may form torroidal pores, are derived (Sawai et al. 2002).

Accession Number:P33046
Protein Name:INDC
Length:144
Molecular Weight:16479.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

eggNOG: maNOG20757
RefSeq: NP_777252.1    XP_001254061.1   
Entrez Gene ID: 282166    786887   
Pfam: PF00666   
KEGG: bta:282166    bta:786887   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0031640 P:killing of cells of another organism

References (4)

[1] “cDNA cloning of the neutrophil bactericidal peptide indolicidin.”  del Sal G.et.al.   1520337
[2] “Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils.”  Selsted M.E.et.al.   1537821
[3] “Fungicidal effect of indolicidin and its interaction with phospholipid membranes.”  Lee D.G.et.al.   12745074
[4] “Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.”  Rozek A.et.al.   11123901
Structure:
1G89   1G8C   1HR1   1QX9   1QXQ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQTQRASLSL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDQLNELSS EANLYRLLEL 
61:	DPPPKDNEDL GTRKPVSFTV KETVCPRTIQ QPAEQCDFKE KGRVKQCVGT VTLDPSNDQF 
121:	DLNCNELQSV ILPWKWPWWP WRRG