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1.C.33.1.6
Lipopolysaccharide (LPS) binding protein precursor

Accession Number:P25230
Protein Name:CP18 aka CAP18
Length:171
Molecular Weight:19805.00
Species:Oryctolagus cuniculus (Rabbit) [9986]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

eggNOG: maNOG20757
RefSeq: NP_001075774.1   
Entrez Gene ID: 100009142   
Pfam: PF00666   

Gene Ontology

GO:0005576 C:extracellular region

References (5)

[1] “Complementary DNA sequence of rabbit CAP18 -- a unique lipopolysaccharide binding protein.”  Larrick J.W.et.al.   1883348
[2] “Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity.”  Hirata M.et.al.   8132348
[3] “A novel granulocyte-derived peptide with lipopolysaccharide-neutralizing activity.”  Larrick J.W.et.al.   8254193
[4] “Identification and characterization of a primary antibacterial domain in CAP18, a lipopolysaccharide binding protein from rabbit leukocytes.”  Tossi A.et.al.   8313956
[5] “The solution structure of the active domain of CAP18 -- a lipopolysaccharide binding protein from rabbit leukocytes.”  Chen C.et.al.   7649303
Structure:
1LYP     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	METHKHGPSL AWWSLLLLLL GLLMPPAIAQ DLTYREAVLR AVDAFNQQSS EANLYRLLSM 
61:	DPQQLEDAKP YTPQPVSFTV KETECPRTTW KLPEQCDFKE DGLVKRCVGT VTRYQAWDSF 
121:	DIRCNRAQES PEPTGLRKRL RKFRNKIKEK LKKIGQKIQG FVPKLAPRTD Y