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1.C.34.1.1
Tachyplesin I precursor.  It's 3-d pore structure has been examined (Lipkin et al. 2017). Its structure/function and toxicity activities have been reviewed (Edwards et al. 2017).

Accession Number:P14213
Protein Name:TAC1
Length:77
Molecular Weight:9349.00
Species:Tachypleus tridentatus (Japanese horseshoe crab) [6853]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Gene Ontology

GO:0005576 C:extracellular region
GO:0042742 P:defense response to bacterium

References (5)

[1] “Antimicrobial tachyplesin peptide precursor. cDNA cloning and cellular localization in the horseshoe crab (Tachypleus tridentatus).”  Shigenaga T.et.al.   2250028
[2] “Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.”  Nakamura T.et.al.   3141410
[3] “Antimicrobial peptide, tachyplesin I, isolated from hemocytes of the horseshoe crab (Tachypleus tridentatus). NMR determination of the beta-sheet structure.”  Kawano K.et.al.   2394727
[4] “A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance.”  Tamamura H.et.al.   8490053
[5] “Separation of large and small granules from horseshoe crab (Tachypleus tridentatus) hemocytes and characterization of their components.”  Shigenaga T.et.al.   8282718
Structure:
1MA2   1MA4   1MA5   1MA6   1WO0   1WO1   2MDB   2RTV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKLVIALCL MMVLAVMVEE AEAKWCFRVC YRGICYRRCR GKRNEVRQYR DRGYDVRAIP 
61:	EETFFTRQDE DEDDDEE