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1.C.35.3.2
Granulosin of 145 aas and 1 TMS.  Functions probably by pore-formation by natural killer (NK) and T lympocyces to combat intracellular parasites, both bacterial and eukaryotic (Dotiwala et al. 2016).

Accession Number:P22749
Protein Name:GNLY aka NKG5 aka LAG2 aka TLA519
Length:145
Molecular Weight:16374.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P22749
eggNOG: maNOG24180
RefSeq: NP_006424.2    NP_036615.2   
Entrez Gene ID: 10578   
Pfam: PF03489   
Drugbank: Drugbank Link   
OMIM: 188855  gene
KEGG: hsa:10578   

Gene Ontology

GO:0005615 C:extracellular space
GO:0006968 P:cellular defense response
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0031640 P:killing of cells of another organism

References (8)

[1] “The isolation and sequence of a novel gene from a human functional T cell line.”  Jongstra J.et.al.   2434598
[2] “A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein.”  Yabe T.et.al.   2212946
[3] “Genomic structure of NKG5, a human NK and T cell-specific activation gene.”  Houchins J.P.et.al.   8423048
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells.”  Krensky A.M.et.al.   10644038
[6] “An antimicrobial activity of cytolytic T cells mediated by granulysin.”  Stenger S.et.al.   9756476
[7] “Biosynthesis of granulysin, a novel cytolytic molecule.”  Hanson D.A.et.al.   10449094
[8] “Granulysin crystal structure and a structure-derived lytic mechanism.”  Anderson D.H.et.al.   12488100
Structure:
1L9L     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATWALLLLA AMLLGNPGLV FSRLSPEYYD LARAHLRDEE KSCPCLAQEG PQGDLLTKTQ 
61:	ELGRDYRTCL TIVQKLKKMV DKPTQRSVSN AATRVCRTGR SRWRDVCRNF MRRYQSRVTQ 
121:	GLVAGETAQQ ICEDLRLCIP STGPL