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1.C.38.1.1
Equinatoxin II (EqtII) binds sphingomyelin specifically and localizes to the Golgi apparatus (Bakrac et al., 2010).  Disrupting the key hydrophobic interaction between V60 and F163 (FraC numbering scheme) in the oligomerization interface of FraC, equinatoxin II (EqtII) and sticholysin II (StII) impairs the pore formation activity (Mesa-Galloso et al. 2016).

Accession Number:P61915
Protein Name:Tenebrosin-C aka EQT2
Length:179
Molecular Weight:19819.00
Species:Actinia tenebrosa (Australian red waratah sea anemone) [6105]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF06369   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042151 C:nematocyst
GO:0046930 C:pore complex
GO:0015267 F:channel activity
GO:0006812 P:cation transport
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis
GO:0046931 P:pore complex assembly

References (2)

[1] “Complete amino acid sequence of tenebrosin-C, a cardiac stimulatory and haemolytic protein from the sea anemone Actinia tenebrosa.”  Simpson R.J.et.al.   1973096
[2] “Purification and characterisation of proteins with cardiac stimulatory and haemolytic activity from the anemone Actinia tenebrosa.”  Norton R.S.et.al.   1970442

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	SADVAGAVID GASLSFDILK TVLEALGNVK RKIAVGVDNE SGKTWTALNT YFRSGTSDIV 
61:	LPHKVPHGKA LLYNGQKDRG PVATGAVGVL AYLMSDGNTL AVLFSVPYDY NWYSNWWNVR 
121:	IYKGKRRADQ RMYEELYYNL SPFRGDNGWH TRNLGYGLKS RGFMNSSGHA ILEIHVSKA