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1.C.39.2.1
Perforin 1 precursor; targets viruses, bacteria and cancer cells (McCormack et al. 2013). It is produced by cytotoxic T lymphocytes and natural killer cells and has been expressed, purified and studied in insect cells (Naneh et al. 2015).

Accession Number:P35763
Protein Name:PERF aka PRF1 aka PFP
Length:554
Molecular Weight:61513.00
Species:Rattus norvegicus (Rat)   [10116]
Location1 / Topology2 / Orientation3: Cytoplasmic granule lumen1 / Multi-pass membrane protein2
Substrate small molecules, large molecules

Cross database links:

Genevestigator: P35763
eggNOG: roNOG06629
Pfam: PF00168    PF01823   

Gene Ontology

GO:0005829 C:cytosol
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0007623 P:circadian rhythm
GO:0019835 P:cytolysis
GO:0045471 P:response to ethanol

References (1)

[1] “Molecular cloning of rat cytolysin.”  Ishikawa H.et.al.   2809217

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MAAYLFLLGL FLLLPRPVPA PCYTATRSEC KQNHKFVPGV WAAGEGVDVT TLRRSSSFPV 
61:	NTGKFLRPDR TCTLCKNALM NDGIQRLPVA IAHWRPHGSH CQRNVATTKV SSTEGVAREA 
121:	AANINNDWRA GLDVNPKPEA NVHVSVAGSH SKIANFAAEK AHQDQYNFNT DTVECRMYSF 
181:	RLAQKPPLHP DFRKALKNLP HNFNSSTEHA YRRLISSYGT HFITAVDLGG RVSVLTALRT 
241:	CQLTLDGLTA DEVGDCLSVE AQVSIGAQAS VSSEYKACEE KKKQHKIATS FHQTYRERHV 
301:	EVLGGPLDSS NDLLFGNQAT PEHFSTWIAS LPTRPDVVDY SLEPLHILLE DSDPKREALR 
361:	QAISHYVMSR ARWRDCNRPC RAGQHKSSRD SCQCVCQDSN VTNQDCCPRQ RGLAKLMVRN 
421:	FQAKGLWGDY ITSTDAYLKV FFGGQEIRTG VVWNNNHPSW SDKMDFGNVL LSTGGPLRVQ 
481:	VWDADNGWDD DLLGTCDKSP KSGFHEVNCP LNHGSIKFIY QANCLPDLTG ETCLEYAPQG 
541:	LLGDPRGNRS GAVW