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1.C.39.3.5
Complement protein C9; targets bacteria (McCormack et al. 2013).  β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).

Accession Number:P48770
Protein Name:CO9 aka C9
Length:547
Molecular Weight:62014.00
Species:Equus caballus (Horse) [9796]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate small molecules, large molecules

Cross database links:

RefSeq: NP_001075419.1   
Entrez Gene ID: 100034183   
Pfam: PF00057    PF01823   
KEGG: ecb:100034183   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005579 C:membrane attack complex
GO:0006957 P:complement activation, alternative pathway
GO:0006958 P:complement activation, classical pathway
GO:0019835 P:cytolysis

References (1)

[1] “Chimeric horse/human recombinant C9 proteins identify the amino acid sequence in horse C9 responsible for restriction of hemolysis.”  Tomlinson S.et.al.   7541424

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSAGRTFAFA ICILEVSVLT AGPTPNYAPE PEQQSGTPLP IDCRMSSWSE WSECDPCLRQ 
61:	MFRSRSIEVF GQFNGQRCVD AVGDRRQCVP TEACEEVEDD CGNDFQCGTG RCIKKRLLCN 
121:	GDNDCGDFSD EDDCENDPRP PCRERVVEES ELARTAGYGI NILGMDPLST PFDNEYYNGL 
181:	CDRVRDGNTL TYYRKPWNLA SLAYETKADK NFRIEHYEQQ IQAFRSVIEE RRSHFNADFT 
241:	LKFTPTEAKK CKQEPEESCN GTDSSENRIF RFAYSKNETY QLFLSYSSKK EKMFLHVKGV 
301:	IQLGKFVMRS RDVVLTTTFL DDIKALPTAY EKGEYIAFLE TYGTHYSSSG SLGGLYELIY 
361:	VLDKASMDQK GVELRDIQRC LGFNLDLSLK DKYEVTAKID KNDCLKRNEK EIVNIMDGSL 
421:	IDDVISLIRG GTRKYAFELK EKLLKGAKTV NVTDFVNWAS SLNDAPVLIS QRLSPIYNLI 
481:	PVKMKDAHQK KQNLERAIED YINEFSVRKC HPCQNGGTVI QIDGQCLCSC PIAFEGIACE 
541:	TGKKKIS