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1.C.39.3.6
Complement protein C9.  β-Hairpins in C8α and C9 play a direct role in MAC membrane penetration and pore formation (Weiland et al. 2014).

Accession Number:P79755
Protein Name:CO9 aka C9
Length:586
Molecular Weight:65198.00
Species:Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) [31033]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate small molecules, large molecules

Cross database links:

eggNOG: fiNOG15406
Pfam: PF00057    PF01823   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005579 C:membrane attack complex
GO:0006957 P:complement activation, alternative pathway
GO:0006958 P:complement activation, classical pathway
GO:0019835 P:cytolysis

References (1)

[1] “Cloning and sequencing of complement component C9 and its linkage to DOC-2 in the pufferfish Fugu rubripes.”  Yeo G.S.H.et.al.   9373156

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRTEAALQLG FCALCVMLAL LGEGMGRELP DPPAVNCVWS RWAPWSSCDP CTNTRRRSRG 
61:	VEVFGQFAGI ACQGSVGDRE YCITNAKCNL PPPRECSDSE FQCESGSCIK LRLKCNGDYD 
121:	CEDGSDEDCE PLRKTCPPTV LDTNEQGRTA GYGINILGAD PRMNPFNNDF FNGRCDKVRN 
181:	PNTLQLDRLP WNIGVLNYQT LVEETASREI YEDSYSLLRE MLKEMSIKVD AGLSFKFKST 
241:	EPSMSNNSLK LDASLEYEKK TMIKDVSELT NIKNKSFMRV KGRLQLSTYR MRSHQLQVAD 
301:	EFVAHVKSLP LEYEKGIYYA FLEDYGTHYT KNGKSGGEYE LVYVLNQDTI KAKNLTERKI 
361:	QECLKIGIEA EFATTSVQDG KAHAKLNKCD DVTTKSQGDV EGKAVVDNVM TSVKGGSLES 
421:	AVTMRAKLNK EGVMDIATYQ NWARTIASAP ALINSEPEPI YMLIPTDIPG ANSRIANLKQ 
481:	ATADYVAEYN VCKCRPCHNG GTLALLDGKC ICMCSNLFEG LGCQNFKGDK ARVPAARPAV 
541:	TQEGNWSCWS SWSNCQGQKR SRTRYCNTEG VLGAECRGEI RSEEYC