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1.C.39.6.1
Sporozoite protein with MAC/Perforin domain (Homologous to Erylysin B) of 810 aas.  Interacts and breaches host cell membranes (Tavares et al. 2014).  CDC/MACPF proteins contain a characteristic four-stranded beta-sheet that is flanked by two alpha-helical bundles, which unfold to form two transmembrane beta-hairpins. Apicomplexan parasites express CDC/MACPFs termed perforin-like proteins (PLPs). Wade and Tweten 2015 present insights into the assembly and regulation of the Apicomplexan CDC (ApiMACPF) molecular pore-forming mechanisms, necessary for osmotically driven rupture of the parasitophorous vacuole and host cell membrane, and cell traversal by these parasites.

Accession Number:B3L016
Protein Name:Sporozoite protein with MAC/Perforin domain
Length:844
Molecular Weight:93826.00
Species:Plasmodium knowlesi (strain H) [5851]
Number of TMSs:2
Substrate small molecules, large molecules

Cross database links:

HEGENOM: HBG630032 HBG630032 HBG630032
Entrez Gene ID: 7318914   
Pfam: PF01823   
KEGG: pkn:PKH_030600    pkn:PKH_030600   

References (2)

[1] “The genome of the simian and human malaria parasite Plasmodium knowlesi.”  Pain A.et.al.   18843368
[2] “The genome of the simian and human malaria parasite Plasmodium knowlesi.”  Pain A.et.al.   18843368

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKPGNINNLL AIWCIIFSIY EYGYVGSLRI GLRRNYSQSR NPDQYGESEV DFRTSGQLRD 
61:	LGKHANILYN NISYNTKNEA SFLNQKKQLD DDDDDDLGDL YIDDDDDAST ATGGGSATSD 
121:	DDDLELPDKD EEGDEDAKNQ QISQDDAESS GREEGLKKNV KLSKQEKLIE DKKEQTNNTF 
181:	KKYLFKDDDE EESKKKLSGK SKSRDSNSLD DDNDKDDSGD DDDSEGDKTR SNTRDAMKKD 
241:	LSVFPGMYFA GIGYDSLFGN PLGESDSLTD PGYRGQIILM NWEFSNKGVA NDLATLQPLN 
301:	GWIRKENACS RAESIKECSS ISDYTKNLTA EASVSGSYMG FGAFSASTGY KKFLQETSKR 
361:	TTKTYLIKSN CVKYTVGLPP YVHWEQTTAF KNAVDGLPPH FIGLEAESEC ASDVYEQKKT 
421:	SEECESVHAW ITFFKTYGTH IIMEAQLGGK ITKVVRVENT SVNQMKKDGI SVKAQVKAQF 
481:	GFASVGGSTN VSSDNSSKTN ENNYEMSEQL VVIGGNPIKD VTKEENLYEW SKTVSTNPMP 
541:	INIRLLPIST IFESDDLKSS YEKALIYYTR LYGFSPHDTM QKDEKDIVKI LTASTTVTNI 
601:	GAPPISAECP HNMVVLFGFV IRQNFWDHTN KLRSYEMEIC ESGMSTCTSK QGSTNKYDVS 
661:	YTYIECGAQA LPFIEQVVNV SGTTYNSLKC PNDYSVLFGF GMATSSGKHQ SALYTYFTPC 
721:	RPGMKSCSLN MNNQDDKSYI YLVCVDATIW TGLNSLSLIA KDDLHTPVNK YKQFNDGELI 
781:	VTCPSEGTIL TGFYGETHTS SPYVKAPFGK CAKSLKACSV HGCGQAIGMH NYRTLFVVAL 
841:	CKND