TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.4.2.1
α-toxin forms large ion permeable (slightly anion-selective) pores with no lipid specificity. It induces rapid cell necrosis in many cell types (Knapp et al., 2009).

Accession Number:Q53482
Protein Name:Alpha-toxin
Length:443
Molecular Weight:49786.00
Species:Clostridium septicum [1504]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate lipids, small molecules, ions

Cross database links:

Pfam: PF01117   

Gene Ontology

GO:0005576 C:extracellular region
GO:0009405 P:pathogenesis

References (2)

[1] “The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin.”  Ballard J.et.al.   7806374
[2] “Cloning, nucleotide sequence and expression of a hemolysin gene of Clostridium septicum.”  Imagawa T.et.al.   8200504

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSKKSFAKKV ICTSMIAIQC AAVVPHVQAY ALTNLEEGGY ANHNNASSIK IFGYEDNEDL 
61:	KAKIIQDPEF IRNWANVAHS LGFGWCGGTA NPNVGQGFEF KREVGAGGKV SYLLSARYNP 
121:	NDPYASGYRA KDRLSMKISN VRFVIDNDSI KLGTPKVKKL APLNSASFDL INESKTESKL 
181:	SKTFNYTTSK TVSKTDNFKF GEKIGVKTSF KVGLEAIADS KVETSFEFNA EQGWSNTNST 
241:	TETKQESTTY TATVSPQTKK RLFLDVLGSQ IDIPYEGKIY MEYDIELMGF LRYTGNARED 
301:	HTEDRPTVKL KFGKNGMSAE EHLKDLYSHK NINGYSEWDW KWVDEKFGYL FKNSYDALTS 
361:	RKLGGIIKGS FTNINGTKIV IREGKEIPLP DKKRRGKRSV DSLDARLQNE GIRIENIETQ 
421:	DVPGFRLNSI TYNDKKLILI NNI