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1.C.40.1.1
Bacterial permeability inducing protein, BPIP precursor, of 487 aas and 1 N-terminal TMS. 

Accession Number:P17213
Protein Name:BPI aka BPIP
Length:487
Molecular Weight:53900.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P17213
eggNOG: prNOG15354
RefSeq: NP_001716.2   
Entrez Gene ID: 671   
Pfam: PF01273    PF02886   
OMIM: 109195  gene
KEGG: hsa:671   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005887 C:integral to plasma membrane
GO:0008289 F:lipid binding
GO:0001530 F:lipopolysaccharide binding
GO:0042742 P:defense response to bacterium
GO:0032715 P:negative regulation of interleukin-6 produc...
GO:0032717 P:negative regulation of interleukin-8 produc...
GO:0043031 P:negative regulation of macrophage activation
GO:0032720 P:negative regulation of tumor necrosis facto...

References (10)

[1] “Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.”  Gray P.W.et.al.   2722846
[2] “Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.”  Wilde C.G.et.al.   7517398
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.”  Wasiluk K.R.et.al.   1937776
[7] “Antibiotic proteins of human polymorphonuclear leukocytes.”  Gabay J.E.et.al.   2501794
[8] “A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein.”  Ooi C.E.et.al.   3667613
[9] “Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein.”  Horwitz A.H.et.al.   8812832
[10] “Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution.”  Beamer L.J.et.al.   9188532
Structure:
1BP1   1EWF     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ QGTAALQKEL 
61:	KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG 
121:	KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT ITCSSCSSHI NSVHVHISKS 
181:	KVGWLIQLFH KKIESALRNK MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL 
241:	VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV 
301:	YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ 
361:	PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELK 
421:	HSNIGPFPVE LLQDIMNYIV PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF 
481:	GADVVYK