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1.C.40.1.2
LBP (lipopolysaccharide binding protein) precursor

Accession Number:P18428
Protein Name:LBP
Length:481
Molecular Weight:53384.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P18428
eggNOG: prNOG13159
HEGENOM: HBG278860
DIP: DIP-90N
RefSeq: NP_004130.2   
Entrez Gene ID: 3929   
Pfam: PF01273    PF02886   
OMIM: 151990  gene
KEGG: hsa:3929   

Gene Ontology

GO:0005615 C:extracellular space
GO:0005634 C:nucleus
GO:0051636 F:Gram-negative bacterial cell surface binding
GO:0051637 F:Gram-positive bacterial cell surface binding
GO:0008289 F:lipid binding
GO:0001530 F:lipopolysaccharide binding
GO:0070891 F:lipoteichoic acid binding
GO:0005102 F:receptor binding
GO:0006953 P:acute-phase response
GO:0006968 P:cellular defense response
GO:0071223 P:cellular response to lipoteichoic acid
GO:0050829 P:defense response to Gram-negative bacterium
GO:0050830 P:defense response to Gram-positive bacterium
GO:0032490 P:detection of molecule of bacterial origin
GO:0045087 P:innate immune response
GO:0006869 P:lipid transport
GO:0015920 P:lipopolysaccharide transport
GO:0031663 P:lipopolysaccharide-mediated signaling pathway
GO:0002281 P:macrophage activation during immune response
GO:0032720 P:negative regulation of tumor necrosis facto...
GO:0008228 P:opsonization
GO:0032755 P:positive regulation of interleukin-6 produc...
GO:0032757 P:positive regulation of interleukin-8 produc...
GO:0043032 P:positive regulation of macrophage activation
GO:0060265 P:positive regulation of respiratory burst in...
GO:0034145 P:positive regulation of toll-like receptor 4...
GO:0032760 P:positive regulation of tumor necrosis facto...
GO:0032496 P:response to lipopolysaccharide

References (8)

[1] “Structure and function of lipopolysaccharide binding protein.”  Schumann R.R.et.al.   2402637
[2] “Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.”  Wilde C.G.et.al.   7517398
[3] “The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved.”  Hubacek J.A.et.al.   9240454
[4] “Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins.”  Kirschning C.J.et.al.   9441745
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[7] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[8] “The BPI/LBP family of proteins: a structural analysis of conserved regions.”  Beamer L.J.et.al.   9568897

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL QSELLRITLP 
61:	DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG LSLSISDSSI RVQGRWKVRK 
121:	SFFKLQGSFD VSVKGISISV NLLLGSESSG RPTVTASSCS SDIADVEVDM SGDLGWLLNL 
181:	FHNQIESKFQ KVLESRICEM IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA 
241:	QMLEVMFKGE IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN 
301:	FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN FSPGNLSVDP 
361:	YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG FLKPGKVKVE LKESKVGLFN 
421:	AELLEALLNY YILNTFYPKF NDKLAEGFPL PLLKRVQLYD LGLQIHKDFL FLGANVQYMR 
481:	V