1.C.40.1.8
Cholesteryl ester transfer protein, CETP of 493 aas and 1 TMS. Involved
in the transfer of neutral lipids, including cholesteryl esters and
triglycerides, among lipoprotein particles. Allows the net movement of
cholesteryl esters from high density lipoproteins/HDL to
triglyceride-rich very low density lipoproteins/VLDL, and the equimolar
transport of triglyceride from VLDL to HDL (Drayna et al. 1987; Morton and Izem 2014).
Regulates reverse cholesterol transport, by which excess
cholesterol is removed from peripheral tissues and returned to the liver
for elimination (Qiu et al. 2007).
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| Accession Number: | P11597 |
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| Protein Name: | Cholesteryl ester transfer protein |
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| Length: | 493 |
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| Molecular Weight: | 54756.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
cholesteryl ester, triglyceride, lipoprotein |
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1: MLAATVLTLA LLGNAHACSK GTSHEAGIVC RITKPALLVL NHETAKVIQT AFQRASYPDI
61: TGEKAMMLLG QVKYGLHNIQ ISHLSIASSQ VELVEAKSID VSIQNVSVVF KGTLKYGYTT
121: AWWLGIDQSI DFEIDSAIDL QINTQLTCDS GRVRTDAPDC YLSFHKLLLH LQGEREPGWI
181: KQLFTNFISF TLKLVLKGQI CKEINVISNI MADFVQTRAA SILSDGDIGV DISLTGDPVI
241: TASYLESHHK GHFIYKNVSE DLPLPTFSPT LLGDSRMLYF WFSERVFHSL AKVAFQDGRL
301: MLSLMGDEFK AVLETWGFNT NQEIFQEVVG GFPSQAQVTV HCLKMPKISC QNKGVVVNSS
361: VMVKFLFPRP DQQHSVAYTF EEDIVTTVQA SYSKKKLFLS LLDFQITPKT VSNLTESSSE
421: SVQSFLQSMI TAVGIPEVMS RLEVVFTALM NSKGVSLFDI INPEIITRDG FLLLQMDFGF
481: PEHLLVDFLQ SLS