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1.C.46.1.1
CNP precursor protein (CNP-22 and CNP-29)

Accession Number:P23582
Protein Name:ANFC aka CNP aka CNP2 aka NPPC
Length:126
Molecular Weight:13246.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate cations

Cross database links:

Genevestigator: P23582
eggNOG: prNOG21394
HEGENOM: HBG125954
RefSeq: NP_077720.1   
Entrez Gene ID: 4880   
Pfam: PF00212   
OMIM: 600296  gene
KEGG: hsa:4880   

Gene Ontology

GO:0005179 F:hormone activity
GO:0006182 P:cGMP biosynthetic process
GO:0003418 P:growth plate cartilage chondrocyte differen...
GO:0003419 P:growth plate cartilage chondrocyte prolifer...
GO:0007168 P:receptor guanylyl cyclase signaling pathway
GO:0008217 P:regulation of blood pressure
GO:0050880 P:regulation of blood vessel size
GO:0019229 P:regulation of vasoconstriction

References (7)

[1] “Gene and precursor structures of human C-type natriuretic peptide.”  Tawaragi Y.et.al.   2018508
[2] “Human C-type natriuretic peptide. Characterization of the gene and peptide.”  Ogawa Y.et.al.   1339402
[3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1.”  Ishizaka Y.et.al.   1472040
[6] “Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).”  Koller K.J.et.al.   1672777
[7] “Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.”  He X.-L.et.al.   11533490
Structure:
1JDP     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPAEEL AEPQAAGGGQ KKGDKAPGGG 
61:	GANLKGDRSR LLRDLRVDTK SRAAWARLLQ EHPNARKYKG ANKKGLSKGC FGLKLDRIGS 
121:	MSGLGC