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1.C.48.1.1
Major prion protein precursor PrP (yielding peptide PrP[106-126])

Accession Number:P23907
Protein Name:PRIO aka PrP aka PRNP
Length:256
Molecular Weight:27915.00
Species:Ovis aries (Sheep) [9940]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate ions

Cross database links:

RefSeq: NP_001009481.1   
Entrez Gene ID: 493887   

Gene Ontology

GO:0031225 C:anchored to membrane
GO:0005794 C:Golgi apparatus
GO:0005886 C:plasma membrane
GO:0008017 F:microtubule binding
GO:0051260 P:protein homooligomerization

References (14)

[1] “Two alleles of a neural protein gene linked to scrapie in sheep.”  Goldmann W.et.al.   1969635
[2] “Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.”  Westaway D.et.al.   7926780
[3] “Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.”  Lee I.Y.et.al.   9799790
[4] “PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNA.”  Goldmann W.et.al.   10466827
[5] “Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed.”  Seabury C.M.et.al.   14970684
[6] “Prion protein gene polymorphisms in healthy and scrapie affected sheep in Greece.”  Billinis C.et.al.   14769911
[7] “The epididymal soluble prion protein forms a high-molecular-mass complex in association with hydrophobic proteins.”  Ecroyd H.et.al.   16029166
[8] “The crystal structure of the globular domain of sheep prion protein.”  Haire L.F.et.al.   15037077
[9] “Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.”  Eghiaian F.et.al.   15240887
[10] “Prion protein NMR structures of cats, dogs, pigs, and sheep.”  Lysek D.A.et.al.   15647367
[11] “Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.”  Goldmann W.et.al.   1681027
[12] “PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.”  Laplanche J.-L.et.al.   8094373
[13] “Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.”  Belt P.B.G.M.et.al.   7897344
[14] “PrP genotype contributes to determining survival times of sheep with natural scrapie.”  Bossers A.et.al.   8887505
Structure:
1G04   1M25   1S4T   1TPX   1TQB   1TQC   1UW3   1XYU   1Y2S   2KTM   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 
61:	GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GGWGQGGSHS QWNKPSKPKT NMKHVAGAAA 
121:	AGAVVGGLGG YMLGSAMSRP LIHFGNDYED RYYRENMYRY PNQVYYRPVD RYSNQNNFVH 
181:	DCVNITVKQH TVTTTTKGEN FTETDIKIME RVVEQMCITQ YQRESQAYYQ RGASVILFSS 
241:	PPVILLISFL IFLIVG