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1.C.48.1.2
Major prion protein, PrP or PRNP, of 253 aas and 3 possible TMSs, N-terminal, middle, and C-terminal. Its primary physiological function is unclear. It has cytoprotective activity against internal or environmental stresses and may play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance, but may play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (Mani et al. 2003; Taylor et al. 2009; Wu et al. 2010).  The mouse orthologue (P04925), particularly the A116V mutant, forms ion channels in lipid membranes (Sabareesan et al. 2016).

Accession Number:P04156
Protein Name:Major prion protein
Length:253
Molecular Weight:27661.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate ions

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP 
61:	HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTNMK HMAGAAAAGA 
121:	VVGGLGGYML GSAMSRPIIH FGSDYEDRYY RENMHRYPNQ VYYRPMDEYS NQNNFVHDCV 
181:	NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV 
241:	ILLISFLIFL IVG