|Protein Name:||CAL1 aka CGRPI aka CALCA aka CALC1|
|Species:||Homo sapiens (Human) |
|Location1 / Topology2 / Orientation3:||Secreted1|
|Substrate||K+, Na+, Ca2+, Cl-|
Cross database links:
|Entrez Gene ID:||796|
GO:0005615 C:extracellular space
GO:0005179 F:hormone activity
GO:0007190 P:activation of adenylate cyclase activity
GO:0007267 P:cell-cell signaling
GO:0051482 P:elevation of cytosolic calcium ion concentr...
GO:0043542 P:endothelial cell migration
GO:0001935 P:endothelial cell proliferation
GO:0007159 P:leukocyte cell-cell adhesion
GO:0045776 P:negative regulation of blood pressure
GO:0045779 P:negative regulation of bone resorption
GO:0010523 P:negative regulation of calcium ion transpor...
GO:0045671 P:negative regulation of osteoclast different...
GO:0001976 P:neurological system process involved in reg...
GO:0032730 P:positive regulation of interleukin-1 alpha ...
GO:0032757 P:positive regulation of interleukin-8 produc...
GO:0045651 P:positive regulation of macrophage different...
GO:0045909 P:positive regulation of vasodilation
GO:0001944 P:vasculature development
 “Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.” Jonas V.et.al. 3872459
 “Structure and methylation of the human calcitonin/alpha-CGRP gene.” Broad P.M.et.al. 2571128
 “Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.” Nelkin B.D.et.al. 6148938
 “Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.” Edbrooke M.R.et.al. 2408883
 “Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.” Steenbergh P.H.et.al. 6610687
 “Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.” Craig R.K.et.al. 3034287
 “Isolation and characterization of human calcitonin gene-related peptide.” Morris H.R.et.al. 6609312
 “Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.” Petermann J.B.et.al. 3492492
 “Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.” Kitamura K.et.al. 1318039
 “Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.” Breeze A.L.et.al. 1988044
 “Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.” Hubbard J.A.M.et.al. 2039456
|Predict TMSs (Predict number of transmembrane segments)|
|FASTA formatted sequence||
1: MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ 61: MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR SGGVVKNNFV PTNVGSKAFG 121: RRRRDLQA