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1.C.5.1.1
ε-toxin (epsilon toxin; ETx) type B precursor, EtxB, of 328 aas.  Forms heptameric pores (Miyata et al. 2002).  However, it has been reported to act on oligodendrocytes causing demyelination without forming pores (Wioland et al. 2015). The toxin acts on the brain, affecting vascular permeability, but also damaging neurons, astrocytes and oligodendrocytes (Freedman et al. 2016).

Accession Number:Q02307
Protein Name:EtxB
Length:328
Molecular Weight:36396.00
Species:Clostridium perfringens [1502]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Gene Ontology

GO:0009405 P:pathogenesis

References (1)

[1] “Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli.”  Havard H.L.et.al.   1729175

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKNLVKSLA IASAVISIYS IVNIVSPTNV IAKEISNTVS NEMSKKASYD NVDTLIEKGR 
61:	YNTKYNYLKR MEKYYPNAMA YFDKVTINPQ GNDFYINNPK VELDGEPSMN YLEDVYVGKA 
121:	LLTNDTQQEQ KLKSQSFTCK NTDTVTATTT HTVGTSIQAT AKFTVPFNET GVSLTTSYSF 
181:	ANTNTNTNSK EITHNVPSQD ILVPANTTVE VIAYLKKVNV KGNVKLVGQV SGSEWGEIPS 
241:	YLAFPRDGYK FSLSDTVNKS DLNEDGTINI NGKGNYSAVM GDELIVKVRN LNTNNVQEYV 
301:	IPVDKKEKSN DSNIVKYRSL YIKAPGIK