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1.C.57.2.1
Toxin B

Accession Number:O82916
Protein Name:TOXB
Length:3169
Molecular Weight:361949.00
Species:Escherichia coli O157:H7 [83334]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate peptides, small molecules

Cross database links:

HEGENOM: HBG086792
RefSeq: NP_052665.1   
Entrez Gene ID: 1789667   
Pfam: PF11996    PF04488   

Gene Ontology

GO:0004197 F:cysteine-type endopeptidase activity
GO:0009405 P:pathogenesis

References (1)

[1] “Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak.”  Makino K.et.al.   9628576

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MIHPGSSLDK AINNTRVKNV STDVKHGQIQ ERKRNFIYKK NDDISSRFKL YSSLVKQKNA 
61:	TEDVVLIGKM ILDEVRSYRT IHNDRNIVSN SGNWKTSFLC NLARLLYSIF NGSNYFCSRE 
121:	GENNSSPSST LLTIHQPEKQ ELLQQKSIKH LPTSNNIDGY IKIRKTRGAE DQTTTITQSL 
181:	IINELLNGVD RNTIPFQKIS ELNDIIHSYE NMQIKNSRKG IEILVKQGEL LSSLINVNKG 
241:	NKQLSDNASK IINLLGIEYQ SHKVDIEPFI HAVWVAGAPP DNTFSYITAF LNTYKDYTYL 
301:	LWIDPNAFGA AKFSGILKNI AMNYAIMRLR RTNPHLAEEM NEVILKIQNI QNETIEFKET 
361:	RERLKELENR YKSLTSETKE KFNVFFLESM IGMQDNYFTY CISNGISNTD DISRLDFLTN 
421:	VLKLSPEVQN DFKSTVEKNK RDIDLLKNTI SQKFGDRFQL RDINTLESFK KPQDYFFYQQ 
481:	EMLLRWNYAA ASDQVRINIL KEYGGIYTDT DILPAYSDKV SQIINEKSDD KRFFEDLKLR 
541:	RIISESILSL IKGEKYSIKH DGLDETTLNQ LNNILSEIEK LTIDDYFKPV ETKVVRDTFK 
601:	IFKRYQKWTE NTWNIRGNNN FMLTHKGSKC IDFILSGQKK QYLELQRIRD NISYNNLFYT 
661:	TEDLKSLNNV AIGGIPAKKY LEHGLFSEYR QDGTIPYVVS TLNISGPDMI MRQMKKYYKS 
721:	LGRIGEVHIK DNKLSDVNFL GVYASSNKDN KSFNWLNPVS VGINDITPDD ESSWAVRNND 
781:	INKILFEKIN CHVPEKLPTS LYYEIDSRSF FQGWDNKSIK HVTEINKDLI KDINLLLTSS 
841:	NIDVKLLIKL DRELYAISSK IDNPLALRSI RTLQLQLANY VTSNTFEPEN TINFIYDFYR 
901:	KKQDDLLSAI KLFSRNDADT KIIVWYNSVM EKNVFLREVI SCVLRSKKVD SYINENKKNL 
961:	SKEDAGALRD YAKLKMKELF SMLDDDGYKK IITTNAYIKE RDKLSGIIYN IENSIISGHE 
1021:	SFDIIRSNQH EWGDLSTVEQ FKKFEFYVKS ELSSAKSIFD DIKNKYITDP ETKRNVLYHQ 
1081:	LDSDIKERIA FLDISHYAYP GSLLEKLQLS GYVFSDINII AEYLLASYGV SGHYSHGVVY 
1141:	PAPSDKLLEL LRRHTKSNSE WIEKITPYVY DILSDNVSNV LRPPLSEEQK KILNDIKLEI 
1201:	SKSVSEQYFM KLTEQKSSVI GIKYSVDFDR YNENLFLSLP INQNLTLPFM YRYFEMLYDI 
1261:	HIGIIENKAN REFIYSKFSS LNLDFLINDE RVLNLEGLIK KYKYLSLSEI HRTLTNSTSF 
1321:	ADISIPLLQT ICPSITTIIK KTEYYGHQLT NAMTVASVVK PYDFSNLGAI NSIDKSVSDV 
1381:	PALHTIVEQA KYNLLSWNDF YNTHASIWDT IARQHKSTNI EFHPQSLLFD RDSKGKCLGL 
1441:	SLLYLDTGGY GGGYQKLRHN IDTASTLYQT KYNDNLKLSN RDDFFLRKTQ RIITMSNELG 
1501:	NNRLKNAQLE VLELKDPILT EGILYQRRIS SLLITTEYHS LALQQISSFW RVTDPNFGHC 
1561:	DFHSLAQALT FIKNITSNRN FSSLYGSGIV KIYFSESLNN WKYIKLPLVQ TGSLLRDIYL 
1621:	TTPEKLSTSG GSLNIMGHLV PVSFIYDIGG VINGNRISES TDVKNKIRSL KINGDILQHY 
1681:	INTHYLSEEQ TQKIKDIVDF LGIQDNTIKV KLESDIKPIS EIQQPLHSIL SRQKEHVKNL 
1741:	LSGLLDEFSN KLRKQGLSLK TNVLSVNNFK ESKINSDTVE VTVTDLQGRL YRVDIDTRVI 
1801:	GLTFKEGINS LSEALEHMNI DAIMSVIGLV QYARMIKMND NISAIDHAGA VSDIKNIVDK 
1861:	FLGGILTLTN NRVYNPGGVS GASLEGFTSS GLEVCASRMG GTAGRYLSNV AKVIKLPLLD 
1921:	IGINIWSLYD SSLNHAKATT QIEYISTAID VSFSSINTAL SIGAIAYPPL AIAIVPITIF 
1981:	SHEVKNYAVY VNQINERHKL WLEAEKYLDN GSAKVLSINK ATGIIDLSNN QVLGNIYLDM 
2041:	RENPPILHGE KSYNSGKNIG SHPDMTDREI MESRAYNFAC TKLSDAGEPD IFGWGDKEIC 
2101:	NSMELSESQL ANGYSNRQWP SQIPVIPEGI YNTVYLGYGE TLRANTEVTL SSTGYFYEIA 
2161:	RAYTDDELSE PLLTVCNQHS HVIGGKEPLT IIIPAIEHGM LGSNLHMIER FKNYNFSISG 
2221:	GKGGIKLMVG GIGDYNIECT PGVRNIISFE QLSRDFNLDL DLSDGRKQNF NFHHPSGFYS 
2281:	GKVMSITQKG INAVVGTKLG YDKIRGNNLD NTFSLGSGGG VIYSGGGSNT YFVPATLQDN 
2341:	LHIYISEKSN GNHIILGDMH SRLSIECHFS NNEREFIKMG YYNGCDVILE SDTIQKIKSF 
2401:	AKNITIQTAD GVMANWDDKL NTLSVYSIDM IAWRDKNKTA KEPLPVDVIQ LTNWRMHNTC 
2461:	SLFYDKYQVD IEANKLTYTV LFPDTELPVQ LNYTSIIYGN HGAKYTFLNS GSKTIDIHIL 
2521:	DKNSDYDTFD FRNIIFEHYT NEIFISFDNQ GGFVISILNN ATSEAANINV FRKNMTSLDS 
2581:	SGSLIYLPSG DIYHISDIYK MSRGRKSFKL NVEKKPDIDD IINVAILETS YLQIKKIPNN 
2641:	DDSDYILCLD NPNLSSYTLN FNDLSGYISS LWDNIRGSFT PFHKNTVNIA PNEKKYISLI 
2701:	GLDKLSFNID VFRQALEVKN KNSYKISKFT WETYGDIVVS PEDRISHLEL DGFNYFSQPE 
2761:	LDTPISDSFS YLYDNFQIVD SDVHIKLLHL NRETKQITPH RIILKRYFID SFAKTSITDR 
2821:	EKNIYPVICD SPDHFTSDIY RHPFRIVLGN KTLYPSEELV KFISTSKEYL SNMDVINNVI 
2881:	VPQKTTKKNK LSIVSLNSNI KNDIVLSGVM TGTSKIFHLN NSGDLLLTTS KTHGGGVVVI 
2941:	FKDFINNWWK YNLTLITVPI DNKLSDNRIN ITPMGIKIQE TVSGNDRLFF YPTPLKNGCF 
3001:	ILHNPLYSNS FPSLYSHELF DLIEAYRNPT YSYLQNNIIN RYIHTVSEYA GKDGIANMSL 
3061:	SIYAYSTCRF WSKESVAVGD TIKLSNYEHI EFSFNSFSKD YFREQNSDIY KIFFKIASSS 
3121:	NSVVVDKNTL TQKNFLENNT FFSITGIDES LYEKHIIFIT LKVIVPSKK