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1.C.57.3.1
Pasteurella multocida toxin (PMT); dermonecrotic toxin (DMT); mitogenic toxin (ToxA) (Baldwin et al., 2004)

Accession Number:P17452
Protein Name:Dermonecrotic toxin
Length:1285
Molecular Weight:146383.00
Species:Pasteurella multocida [747]
Location1 / Topology2 / Orientation3: Cytoplasm1 / Single-pass membrane protein2
Substrate peptides, small molecules

Cross database links:

Pfam: PF11647   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0033644 C:host cell membrane
GO:0016021 C:integral to membrane
GO:0009405 P:pathogenesis

References (3)

[1] “The complete nucleotide sequence of the Pasteurella multocida toxin gene and evidence for a transcriptional repressor, TxaR.”  Petersen S.K.et.al.   2201870
[2] “Sequence of the dermonecrotic toxin of Pasteurella multocida ssp. multocida.”  Buys W.E.C.M.et.al.   2339066
[3] “Sequence analysis of the potent mitogenic toxin of Pasteurella multocida.”  Lax A.J.et.al.   2269370
Structure:
2EBF   2EBH   2EC5     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTKHFFNSD FTVKGKSADE IFRRLCTDHP DKQLNNVKWK EVFINRFGQM MLDTPNPRKI 
61:	VEKIINEGLE KQGLKNIDPE TTYFNIFSSS DSSDGNVFHY NSLSESYRVT DACLMNIFVE 
121:	RYFDDWDLLN SLASNGIYSV GKEGAYYPDH DYGPEYNPVW GPNEQIYHSR VIADILYARS 
181:	VWDEFKKYFM EYWQKYAQLY TEMLSDTFLA MAIQQYTRQT LTDEGFLMVC NTYYGNKEEV 
241:	QITLLDIYGY PSTDIICIEQ KGLPTPKVIL YIPGGTQPFV EFLNTDDLKQ WIAWHLKDNK 
301:	HMVAFRKHFS LKQRQEGETF TGIDKALQYI AEESPEWPAN KYILYNPTHL ETENLFNIMM 
361:	KRTEQRMLED SDVQIRSNSE ATRDYALSLL ETFISQLSAI DMLVPAVGIP INFALSATAL 
421:	GLSSDIVVNG DSYEKRKYGI GSLVQSALFT GINLIPVISE TAEILSSFSR TEEDIPAFFT 
481:	EEQALAQRFE IVEEELHSIS PDDPPREITD ENLHKIRLVR LNNENQPLVV LRRLGGNKFI 
541:	RIEPITFQEI KGSLVSEVIN PVTNKTYYVS NAKLLGGSPY SPFRIGLEGV WTPEVLKARA 
601:	SVIGKPIGES YKRILAKLQR IHNSNILDER QGLMHELMEL IDLYEESQPS SERLNAFREL 
661:	RTQLEKALYL PEMEALKKQI LQIPNKGSGA ARFLLRTAMN EMAGKTSEST ADLIRFALQD 
721:	TVISAPFRGY AGAIPEAIDF PVKYVIEDIS VFDKIQTNYW ELPAYESWNE GSNSALLPGL 
781:	LRESQSKGML SKCRIIENSL YIGHSYEEMF YSISPYSNQV GGPYELYPFT FFSMLQEVQG 
841:	DLGFEQAFAT RNFFNTLVSD RLSLMENTML LTESFDYTPW DAIYGDINYD EQFAAMSINE 
901:	RIEKCMNTYR GVAFQNSSKS IDFFLNNLTT FIDNGLTEIA ISDLPYDIVQ QEISQFLQGS 
961:	NEWKTLDAML FNLDKGDING AFRKLLQSAK DNNIKFRAIG HSDNSVPPFN NPYKSLYYKG 
1021:	NIIAEAIEKL DREGQKFVVF ADSSLLNSTP GTGRPMPGLV QYLKIPATVV DSDGAWQFLP 
1081:	DVASSRVPIE VTELENWQVL TPPQGKILGL KQFKLTAGFP TEQSRLPLLE NSVSEDLREE 
1141:	LMQKIDAIKN DVKMNSLVCM EAGSCDSVSP KVAARLKDMG LEAGMGASIT WWRREGGMEF 
1201:	SHQMHTTASF KFAGKEFAVD ASHLQFVHDQ LDTTILILPV DDWALEIAQR NRAINPFVEY 
1261:	VSKTGNMLAL FMPPLFTKPR LTRAL