TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.57.3.4
RTX (repeat in toxin) cytotoxin, also called the "multifunctional-autoprocessing RTX" (MARTXVv) toxin, or Vibrio vulnificus cytotoxin (VVC) exists in at least four distinct variants of rtxA1 that encode toxins with different arrangements of effector domains that arose by recombination.  VVC, in addition to being a pore-forming toxin, may be a transmembrane toxin with the ability to induce apoptosis in human vascular endothelial cells and tumor cells (Zhao et al. 2009).

Accession Number:Q7MDK6
Protein Name:RTX (Repeat in toxin) cytotoxin
Length:5206
Molecular Weight:556209.00
Species:Vibrio vulnificus (strain YJ016) [196600]
Location1 / Topology2 / Orientation3: Cytoplasm1 / Single-pass membrane protein2
Substrate peptides, small molecules

Cross database links:

eggNOG: COG2931
HEGENOM: HBG636859
RefSeq: NP_937086.1   
Entrez Gene ID: 2621888   
Pfam: PF00561    PF11713    PF11647    PF07634   
BioCyc: VVUL196600:VVA1030-MONOMER   
KEGG: vvy:VVA1030   

References (1)

[1] “Comparative genome analysis of Vibrio vulnificus, a marine pathogen.”  Chen C.-Y.et.al.   14656965

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGKPFWRSVE YFFTGNYSAD DGNNSIVAIG FGGEIHAYGG DDHVTVGSIG ATVYTGSGND 
61:	TVVGGSAYLR VEDTTGHLSV KGAAGYADIN KSGDGNVSFA GAAGGVSIDH LGNHGDVSYG 
121:	GAAAYNGITR KGLSGNVTFK GAGGYNALWH ETNQGNLSFA GAGAGNKLDR TWFNRYQGSR 
181:	GDVTFDGAGA ANSISSRVET GNITFRGAGA DNHLVRKGKV GDITLQGAGA SNRIERTRQA 
241:	EDVYAQTRGN IRFEGVGGYN SLYSDVAHGD IHFSGGGAYN TITRKGSGSS FDAQGMEYAK 
301:	AEDIVLTAAQ MHGLSIDNGN KFHAVTAVKS EREPNTYLFA IADGTYTKIN KVRLYNDPET 
361:	GKLKYYSEAW FKRGNHLAEL ARSDVSSAGG FEVNPINGGY TLSNIAVEHQ QSLTVHAVEK 
421:	DLTEYEWVTY ANGALIDAKD VALSEAKMGG HAISTDGTTV DVQAVKSNRK PNTYVYAKVL 
481:	GPYTKIVVVE LANDPKTGAL KYQARSWYKE GNHTANLANE DISSANGYHS MGKGGYSLSD 
541:	LHYSVNAVRS TSETVADIDE YTDQTLFKPA TDSGESSGDV RFNGAGGGNV IKSNVTRGNV 
601:	YFNGGGIANV ILHSSQFGHT EFNGGGAANV IVKSGEEGDL TFRGAGLANV LVHQSKQGKM 
661:	DVYAGGAVNV LVRIGDGQYL AHLLAYGNIS VHKGNGNSRV VMLGGYNTHT QIGSGNGLWL 
721:	AAGGFNVMTQ VGKGDVASVL AGGANVLTKV GDGDLTAGML GGANVITHIS GDNETSNTTA 
781:	VALGGANILT KKGKGNTLAV MGGGANVLTH VGDGTTTGVM VGGANILTKV GNGDTTGIML 
841:	GVGNVLTHVG DGQTLGVMGA AGNIFTKVGD GTSIAVMIGA GNIFTHVGEG NAWALMGGLG 
901:	NVFTKVGNGD ALALMVAEAN VFTHIGDGMS VALMLAKGNV ATKVGNGTTL AAMVGNANIF 
961:	THVGSGSTFA AMIGQANIMT KVGNDLTAAL MVGKANIYTH VGDGTSLGIF AGEVNVITKV 
1021:	GNGTTLAAMF GKANIMTHVG DGLTGVLALG EANIVTKVGD DFMGVVAAAK ANVVTHVGDA 
1081:	TTAAVLAGKG NILTKVGEGT TVGLLISDIG NVMTHVGDGT TIGIAKGKAN IITKVGDGLG 
1141:	VNVAWGQANV FTQVGDGDRY NFAKGEANII TKVGDGQEVS VVQGKANIIT HVGNGDDYTG 
1201:	AWGKANVITK VGNGRNVVLA KGEANIVTQV GDGDSFNALW SKGNIVTKVG DGMQVTAAKG 
1261:	KANITTTVGD GLSVTAAYGD ANINTKVGDG VSVNVAWGKY NINTKVGDGL NVAVMKGKAN 
1321:	ANIHVGDGLN INASYAQNNV AIKVGNGDFY SLAVASSNTS SNKLSALFDN IKQTLLGVGG 
1381:	SQAINYLVQG DEASSSGTQK GRGAIATPEI TKLDGFQMEA IEEVGSDLGD SLTGSVTKVD 
1441:	TPDLNKMQNA LDVDGSADQT QAPNLIVNGD FEQGDRGWKS THGVEASYSG NVYGVNGEGH 
1501:	GARVTELDTY TNTSLYQDLT DLTEGEVIAV SFDFAKRAGL SNNEGIEVLW NGEVVFSSSG 
1561:	DASAWQQKTL KLTAHAGSNR IEFKGTGHND GLGYILDNVV AKSESSQQAN AVSEHATQNQ 
1621:	ASQNALSDKE CAEADRQRLE QEKQKQLDAV AGSQSQLEST DQQALENNGQ AQRDAVKEES 
1681:	EAVTAELTKL AQGLDVLDGQ ATHTGESGDQ WRNDFAGGLL DGVQSQLDDA KQLANDKIAA 
1741:	AKQTQSDNNS KVKESVAKSE AGVAKGEQNR AGAEQDIAEA KADAETRKAD AVAKSNDAKQ 
1801:	AESDAHSAAN DAQSRGDRDA MNAENKANQA QNDAKGTKQN EGDRPDREGV AGSGLSGNAH 
1861:	SVEGAGETGS HVNTDSPTNA DGRFSEGLSE QEQEALEGAT NAVNRLQINA GIRGKNSGST 
1921:	ITSMFTETNS DSIVVPTTAS QDVVRQEIRI SGVNLEGLGE TSHDSAESLV AARAEKVANL 
1981:	YRWLDTDNDV ATDKYVPVPG FERVDADVSD EVKQRMIQSM SGYIEHTDNQ VPKDQAEALA 
2041:	TLFVESTLDY DWDKRVEFLT KLESYGYSFE APHAEKSIVS FWSGKNFKQY RDVLDNAQTD 
2101:	GKKVVYDIDV KGNAFAIDLN KHLMRWGGLF LDPDNAEQNQ LKSSIDAATF SNTGFWSSVY 
2161:	ATGAQNDVYV IAEGGVRLGN YFWNVELPAL RQLQREGLVG EIRLLDKPVS EYKDLPADQI 
2221:	GRRLTDAGVA VKVRFDALSH ERQAELLADN PDGYKADTLV ELDVKLSAID SMLRESLPFY 
2281:	SLRTERNLLV QEGEEGFEVR SWPGIDGKSK TILLDNPEDA AQQKSIERFI LANFDNFEQM 
2341:	PDELFLVDNK VLSHHDGRTR IIAQKEDGAW TYNTNVELMS VTELLDAAHV NGKVRGDSYQ 
2401:	QVIDALTEYH ASTVEHADYE LESVEKLLNL RKQIEGYVLG HPDSGRVEAM NSLLNQVNSR 
2461:	LEEVSVLAVS EQSIKAHDSF SRLYDQLDNA NLKESKHLYL DGNGDFVTKG KGNLATIDQL 
2521:	GGSDAVLEKV KAAVTHEYGQ VVADTIFAGL SANDLAKDGK GIDIAGLNKV HQAIEQHMSP 
2581:	VSATMYIWKP SDHSALGHAA LQIGQGRTQL EGQAAADFNK QNYVSWWPLG SKSSNIRNIF 
2641:	NVATEDQPDL KLRWSDFSQP AHQNDTLEHD MASEENDGFG LKDGETKLKR FIEKLNAAKG 
2701:	IDASYKDASE GYASVLLGNP DMLASTGIPA HVFQPFVDQW NDTSYDMMDV ANRFAEELQK 
2761:	QAQASGDPAL VEKRIDNVVR LFAERALEEI EAFKASQADE GRVFRINLEG LDVAAMQAEW 
2821:	NRLSNDPDAR YQLLTKNCSS TVAKVLKAGG ADKLIGHTWR PKFGVWTPTE LFNFGQALQE 
2881:	AQLEIAAKKQ SHQVTDVLDA LSGNEKHKEN VAIENDGTPP RDKESLSPLT RFLNNELYGE 
2941:	KDARRKIGEI TQTLLDHAVE NGESQKVTLK GEVGRLTGYY HQGAASSEGE TSATSGKVVL 
3001:	FLHGSGSSAE EQASEIRNHY QKQGIDMLAV NLRGYGESDG GPSEKGLYQD ARTMFNYLVN 
3061:	DKGIDPSNII IHGYSMGGPI AADLARYAAQ NGQAVSGLLL DRPMPSMTKA ITAHEMANPA 
3121:	GIVGAIAKAV NGQFSVEKNL KGLPKETPIL LLTDNEGLGE EGEKLRAKLA IAGYNVTGEQ 
3181:	TFYGHEASNR LMGQYADQIV SGLFNAEQAA VEAGEVLKGL EKDFKRYGDA LKPDTSVPGK 
3241:	SKDIRTTKDF LNGYKNDHAK EIVDGFRSDM SIKQLVDLFV KGNWSAEQKG ALAWEIESRA 
3301:	LKVTFQNKSE KYNRLFREIA SAGVVDAKAT EQLAPQLMLL NLSNDGFGGR CDPLSKLVLV 
3361:	AKQLENDGQV GVARQLLEKM YSAAAVLSNP TLYSDSEKAN ASKLLSSLAA IHAKNPMHDT 
3421:	SMKVWQEKLE GKQALTVNGV VEKITDASAN GKPVLLELDA PGHAMAAWAK GSGDDRVYGF 
3481:	YDPNAGIVEF SSAEKFGDYL TRFFGKSDLN MAQSYKLGKN DAGEAIFNRV VVMDGNTLAS 
3541:	YKPTFGDKTT MQGILDLPVF DATPIKKPTG GVASDLEALG DKTKVVVDLA QIFTVQELKE 
3601:	RAKVFAKPIG ASYQGILDQL DLVHQAKGRD QIAASFELNK KINDYIAEHP TSGRNQALTQ 
3661:	LKKQVTNALF IGKMQVAQAG IDAIAQTRPE LAARIFMVAI EEANGKHVGL TDMMVRWANE 
3721:	DPYLAPKHGY KGETPSDLGF DAKYHVDLGE HYADFKQWLE TSQSNGLLSK ATLDESTKTV 
3781:	HLGYSYQELQ DLTGAESVQM AFYFLKEAAK KADPISGDSA EMILLKKYAD QSYLSQLDSD 
3841:	RMDQIEGIYR SSHETDIDAW DRRYSGTGYD ELTNKLASAT GVDEQLAVLL DDRKGLLIGE 
3901:	VHGSDVNGLR FVNEQMDALK KQGVTVIGLE HLRSDLAQPL IDRYLATGVM SSELSAMLKT 
3961:	KHLDVTLFEN ARANGMRIVA LDANSSARPN VQGTEHGLMY RAGAANNIAV EVLQNLPDGE 
4021:	KFVAIYGKAH LQSHKGIEGF VPGITHRLDL PALKVSDSNE FTVEQDDVSL RVVYDDVANK 
4081:	PKITFKDSLS GANTALHNQN VNDWERVVVT PTADGGESRF DGQIIVQMEN DDVVAKAAAN 
4141:	LAGKHPESSV VVQIDSDGNY RVVYGDPSKL DGKLRWQLVG HGRDDSESNN TRLSGYSADE 
4201:	LAVKLAKFQQ SFNQAENINN KPDHISIVGC SLVSDDKQKG FGHQFINAMD ANGLRVDVSV 
4261:	RSSELAVDEA GRKHTKDANG DWVQKAENNK VSLSWDEQGE VVAKDERIRN GIAEGDIDLS 
4321:	RIGVSDVDEP ARGAIGDNND VFDAPEKRKA ETETSSSSAN NKLSYSGNIQ VNVGDGEFTA 
4381:	VNWGTSNVGI KVGTGGFKSL AFGDNNVMVH IGNGESKHSF DIGGYQALEG AQMFIGNRNV 
4441:	SFNLGRSNDL IVMMDKSIPT PPLVNPFDGA ARISGVLQSI ATSGEGQDWL AAQEQQWTLS 
4501:	GAKKFVKDMS GLDQSSSVDY TSLVELDSQN ERSSRGLKHD AEAALNKQYN QWLSGNSDSD 
4561:	TSKLSRADKL RQANEKLAFN FAVGGQGADI QVTTGNWNFM FGDNIQSILD TNLGSLFGLM 
4621:	TQQFSATGQA KTTFTYTPED LPRQLKNKLL GQLAGVGAET TLADIFGVDY TASGQIVSRN 
4681:	GEAVDGVAIL KEMLEVIGEF SGDQLQAFVD PAKLLDSLKA GINMGADGIK SFAETHGLKE 
4741:	KAPEEEEDNS SVSVNGASVN SAQGATVADG STETAETPDR AFGFNSLNLP NLFATIFSQD 
4801:	KQKEMKSLVE NLKENLTADL LNMKEKTFDF LRNSGHLQGD GDINISLGNY NFNWGGDGKD 
4861:	LGAYLGDNNN FWGGRGDDVF YATGTSNIFT GGEGNDMGVL MGRENMMFGG DGNDTAVVAG 
4921:	RINHVFLGAG DDQSFVFGEG GEIDTGSGRD YVVTSGNFNR VDTGDDQDYS VTIGNNNQVE 
4981:	LGAGNDFANV FGNYNRINAS AGNDVVKLMG YHAVLNGGEG EDHLIAAAIS KFSQFNGGEG 
5041:	RDLMVLGGYQ NTFKGGTDVD SFVVSGDVID NLVEDIRSED NIVFNGIDWQ KLWFERSGYD 
5101:	LKLSILRDPA SDSDQAKFEH IGSVTFSDYF NGNRAQVIIA MGEKDATGER EYTTLSESAI 
5161:	DALVQAMSGF DPQAGDNGFI DNLDSKSRVA ITTAWADVVH KKGITV