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1.C.63.1.1
α-latrotoxin

Accession Number:P23631
Protein Name:Alpha-latrotoxin
Length:1401
Molecular Weight:156857.00
Species:Latrodectus mactans (Black widow spider) [6925]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF00023   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0044218 C:other organism cell membrane
GO:0042734 C:presynaptic membrane
GO:0006887 P:exocytosis
GO:0009405 P:pathogenesis
GO:0007268 P:synaptic transmission

References (7)

[1] “Cloning and structure of cDNA encoding alpha-latrotoxin from black widow spider venom.”  Kiyatkin N.I.et.al.   1977615
[2] “Alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.”  Ichtchenko K.et.al.   9799228
[3] “Structure of tryptic fragments of a neurotoxin from black widow spider venom.”  Volkova T.M.et.al.   1888339
[4] “Black widow spider toxins: the present and the future.”  Grishin E.V.et.al.   9792186
[5] “Tetramerisation of alpha-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca(2+)-dependent vesicular exocytosis from synaptosomes.”  Ashton A.C.et.al.   10865132
[6] “Alpha-Latrotoxin and its receptors.”  Ushkaryov Y.A.et.al.   18064415
[7] “Structure of alpha-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores.”  Orlova E.V.et.al.   10625427

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MISVGEIMER ANHSLVRMRR EGEDLTLEEK AEICSELELQ QKYVDIASNI IGDLSSLPIA 
61:	GKIAGTIAAA AMTATHVASG RLDIEQTLLG CSDLPFDQIK EVLENRFNEI DRKLDSHSAA 
121:	LEEITKLVEK SISVVEKTRK QMNKRFDEVM KSIQDAKVSP IISKINNFAR YFDTEKERIR 
181:	GLKLNDYILK LEEPNGILLH FKESRTPTDD SLQAPLFSII EEGYAVPKSI DDELAFKVLY 
241:	ALLYGTQTYV SVMFFLLEQY SFLANHYYEK GYLEKYDEYF NSLNNVFLDF KSSLVGTGTS 
301:	NNEGLLDRVL QVLMTVKNSE FLGLEKNGVD EMLNEKINLF NKIKEEIEGK QKMTLSETPE 
361:	NFAQISFDKD ITTPIGDWRD GREVRYAVQY ASETLFSKIS HWSDPVSVRE KACPTLRMPV 
421:	DQTRRNVLVF RKFDSSKPQL VGEITPYLSN FIDIDRDLYN AASNPDSAVG FKEFTKLNYD 
481:	GANIRATFDH GRTVFHAAAK SGNDKIMFGL TFLAKSTELN QPDKKGYTPI HVAADSGNAG 
541:	IVNLLIQRGV SINSKTYHFL QTPLHLAAQR GFVTTFQRLM ESPEININER DKDGFTPLHY 
601:	AIRGGERILE AFLNQISIDV NAKSNTGLTP FHLAIIKNDW PVASTLLGSK KVDINAVDEN 
661:	NITALHYAAI LGYLETTKQL INLKEINANV VSSPGLLSAL HYAILYKHDD VASFLMRSSN 
721:	VNVNLKALGG ITPLHLAVIQ GRKQILSLMF DIGVNIEQKT DEKYTPLHLA AMSKYPELIQ 
781:	ILLDQGSNFE AKTNSGATPL HLATFKGKSQ AALILLNNEV NWRDTDENGQ MPIHGAAMTG 
841:	LLDVAQAIIS IDATVVDIED KNSDTPLNLA AQNSHIDVIK YFIDQGADIN TRNKKGLAPL 
901:	LAFSKKGNLD MVKYLFDKNA NVYIADNDGM NFFYYAVQNG HLNIVKYAMS EKDKFEWSNT 
961:	DNNRRDECPN EECAISHFAV CDAVQFDRIE IVKYFVGTLG NFAICGPLHQ AARYGHLDIV 
1021:	KYLVEEEFLS VDGSKTDTPL CYASENGHFT VVQYLVSNGA KVNHDCGNGM TAIDKAITKN 
1081:	HLQVVQFLAA NGVDFRRKNS RGTTPFLTAV AENALHIAEY LIREKRQDIN INEQNVDKDT 
1141:	ALHLAVYYKN LQMIKLLIKY GIDVTIRNAY DKTALDIAID AKFSNIVEYL KTKSGKFRRE 
1201:	YKSSYGERSL LQTNQISNFI DRKNIEHDHP LFINADNESS ELFSKTASNI DVIGTLLLID 
1261:	VLIRYFSKQG YISKESDSAS DGITQAAALS ITEKFEDVLN SLHNESAKEQ VDLAEVHGKV 
1321:	YAALKSGRNS QIHQILCSSL NSISTLKPED MEKLESVIMN SHSSVSLPEV TDSANEAYGE 
1381:	TLHLFGESCL HSDGILTKKL M