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1.C.63.1.2
α-latroinsectotoxin precursor (α-LIT) (1411aas) (Shatursky et al., 2007)

Accession Number:Q02989
Protein Name:α-LIT
Length:1411
Molecular Weight:157806.00
Species:Latrodectus mactans (Black widow spider) [6925]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Pfam: PF00023   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0044218 C:other organism cell membrane
GO:0042734 C:presynaptic membrane
GO:0006887 P:exocytosis
GO:0009405 P:pathogenesis
GO:0007268 P:synaptic transmission

References (4)

[1] “Cloning and structural analysis of (alpha)-latroinsectotoxin cDNA: abundance of ankyrin-like repeats.”  Kiyatkin N.N.I.et.al.   8477689
[2] “Black widow spider toxins: the present and the future.”  Grishin E.V.et.al.   9792186
[3] “Tetramerisation of alpha-latrotoxin by divalent cations is responsible for toxin-induced non-vesicular release and contributes to the Ca(2+)-dependent vesicular exocytosis from synaptosomes.”  Ashton A.C.et.al.   10865132
[4] “The geometry of the ionic channel lumen formed by alpha-latroinsectotoxin from black widow spider venom in the bilayer lipid membranes.”  Shatursky O.Y.et.al.   17764656

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	ACSSPEVSIF HFFVYAGSFV KNFKKMKGSS AISKREMSRA DQCKLLAYTA VGYETVGNVA 
61:	ADIASIEGAN LVAAPVAAGG HLGKGLTDAA MIAMDCSSIP FEEIKEILNK EFKEMGRKLD 
121:	KNTEALEHVS KLVSKTLSTV EKIRVEMREG FKLVIETIEN IATKEIVFDI NKIVQYFNNE 
181:	RENINSRQKE EFVAKLQEPA PGNFLLYLRN SRTSESGTLY SLLFRIIDQE LAIPNNAGDN 
241:	NAIQALYALF YGTETFISIM FYLVKQYSYL AEYHYQKGNL EEFNTNFDHM KIVFQDFKFS 
301:	LIGINQNTKP LVDEVLNVLN NVKNKSFIRN VQNKLFYDLM KQTESLLELK KEIANMELPI 
361:	IDETPRLSIS ISFKERSDDK PVDTPLLKWD KGKEVKYAIQ FEQDGKFSKI SSWSKPVTVQ 
421:	HLACPFISVD KDRRNRLIFR QFGDQIPELV GTLRGSQVEF RDIHRDLYNA AQVPYAREAL 
481:	SISRTLIQNG ANVSETFELG RGAIHAAASA GNYDVGELLL NKDINLLEKA DKNGYTPLHI 
541:	AADSNKNDFV MFLIGNNADV NVRTKSDLFT PLHLAARRDL TDVTQTLIDI TEIDLNAQDK 
601:	SGFTPLHLSI SSTSETAAIL IRNTNAVINI KSKVGLTPLH LATLQNNLSV SKLLAGKGAY 
661:	LNDGDANGMT PLHYAAMTGN LEMVDFLLNQ QYININAATK EKKWTPLHLA ILFKKNDVAE 
721:	RLLSDENLNI RLETNGGINP LHLASATGNK QLVIELLAKN ADVTRLTSKG FSALHLGIIG 
781:	KNEEIPFFLV EKGANVNDKT NSGVTPLHFA AGLGKANIFR LLLSRGADIK AEDINSQMPI 
841:	HEAVSNGHLE IVRILIEKDP SLMNVKNIRN EYPFYLAVEK RYKDIFDYFV SKDANVNEVD 
901:	HNGNTLLHLF SSTGELEVVQ FLMQNGANFR LKNNERKTFF DLAIENGRLN IVAFAVEKNK 
961:	VNLQAAHRGK TILYHAICDS AKYDKIEIVK YFIEKLNESE CNPLHEAAAY AHLDLVKYFV 
1021:	QERGINPAEF NEENQASPFC ITIHGAPCGY SLDCDTPDRL EVVEYLSDKI PDINGKCDVQ 
1081:	ENTPITVAIF ANKVSILNYL VGIGADPNQQ VDGDPPLYIA ARQGRFEIVR CLIEVHKVDI 
1141:	NTRNKERFTA LHAAARNDFM DVVKYLVRQG ADVNAKGIDD LRPIDIAGEK AKAYLQSSRF 
1201:	LRSGHSFQSN EIDSFGNTIH GISMSARTND KLTQQISSKG TRSDSNSTEG KMHSENVHVR 
1261:	SIDVNGALLL LDFMIRVFAS KKTNFAPYGS RIKTRSAAEA QAEALIMTER FENLLSGLIG 
1321:	DPIPDSIDFS NVHSKIYKAI MSGRRSVISE MLCSFAEEYS KLNHESIKQL LSEFETLTTT 
1381:	KASEIHIEES VPYAPFEICE LKVNSNVSQI K