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1.C.7.1.1
Diphtheria toxin (DT)

Accession Number:P00587
Protein Name:DTX aka DT
Length:560
Molecular Weight:60815.00
Species:Corynephage omega [10714]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

DIP: DIP-370N
Drugbank: Drugbank Link   

Gene Ontology

GO:0005576 C:extracellular region
GO:0047286 F:NAD+-diphthamide ADP-ribosyltransferase act...
GO:0009405 P:pathogenesis

References (1)

[1] “The complete nucleotide sequence of the gene coding for diphtheria toxin in the corynephage omega (tox+) genome.”  Ratti G.et.al.   6314249

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSRKLFASIL IGALLGIGAP PSAHAGADDV VDSSKSFVME NFSSYHGTKP GYVDSIQKGI 
61:	QKPKSGTQGN YDDDWKGFYS TDNKYDAAGY SVDNENPLSG KAGGVVKVTY PGLTKVLALK 
121:	VDNAETIKKE LGLSLTEPLM EQVGTEEFIK RFGDGASRVV LSLPFAEGSS SVEYINNWEQ 
181:	AKALSVELEI NFETRGKRGQ DAMYEYMAQA CAGNRVRRSV GSSLSCINLD WDVIRDKTKT 
241:	KIESLKEHGP IKNKMSESPN KTVSEEKAKQ YLEEFHQTAL EHPELSELKT VTGTNPVFAG 
301:	ANYAAWAVNV AQVIDSETAD NLEKTTAALS ILPGIGSVMG IADGAVHHNT EEIVAQSIAL 
361:	SSLMVAQAIP LVGELVDIGF AAYNFVESII NLFQVVHNSY NRPAYSPGHK TQPFLHDGYA 
421:	VSWNTVEDSI IRTGFQGESG HDIKITAENT PLPIAGVLLP TIPGKLDVNK SKTHISVNGR 
481:	KIRMRCRAID GDVTFCRPKS PVYVGNGVHA NLHVAFHRSS SEKIHSNEIS SDSIGVLGYQ 
541:	KTVDHTKVNS KLSLFFEIKS