TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.73.1.2
The cholix toxin.  The NAD-dependent ADP-ribosyltransferase (ADPRT) catalyzes transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2), thus arresting protein synthesis. It may use the eukaryotic pro-low-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells,  Cholix toxin shares structural and functional properties with Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae diphtheria toxin (Lugo and Merrill 2015).

Accession Number:Q5EK40
Protein Name:Cholix toxin
Length:666
Molecular Weight:74293.00
Species:Vibrio cholerae [666]
Number of TMSs:1
Substrate toxin protein

Cross database links:

Structure:
2Q5T   2Q6M   3ESS   3KI0   3KI1   3KI2   3KI3   3KI4   3KI5   3KI6   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MYLTFYLEKV MKKMLLIAGA TVISSMAHPT FAVEDELNIF DECRSPCSLT PEPGKPIQSK 
61:	LSIPSDVVLD EGVLYYSMTI NDEQNDIKDE DKGESIITIG EFATVRATRH YVNQDAPFGV 
121:	IHLDITTENG TKTYSYNRKE GEFAINWLVP IGEDSPASIK ISVDELDQQR NIIEVPKLYS 
181:	IDLDNQTLEQ WKTQGNVSFS VTRPEHNIAI SWPSVSYKAA QKEGSRHKRW AHWHTGLALC 
241:	WLVPMDAIYN YITQQNCTLG DNWFGGSYET VAGTPKVITV KQGIEQKPVE QRIHFSKGNA 
301:	MSALAAHRVC GVPLETLARS RKPRDLTDDL SCAYQAQNIV SLFVATRILF SHLDSVFTLN 
361:	LDEQEPEVAE RLSDLRRINE NNPGMVTQVL TVARQIYNDY VTHHPGLTPE QTSAGAQAAD 
421:	ILSLFCPDAD KSCVASNNDQ ANINIESRSG RSYLPENRAV ITPQGVTNWT YQELEATHQA 
481:	LTREGYVFVG YHGTNHVAAQ TIVNRIAPVP RGNNTENEEK WGGLYVATHA EVAHGYARIK 
541:	EGTGEYGLPT RAERDARGVM LRVYIPRASL ERFYRTNTPL ENAEEHITQV IGHSLPLRNE 
601:	AFTGPESAGG EDETVIGWDM AIHAVAIPST IPGNAYEELA IDEEAVAKEQ SISTKPPYKE 
661:	RKDELK