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1.C.74.1.2
α-bungarotoxin isoform A31 (α-BTX A31) (blocks activity of the nicotinic acetylcholine receptor (TC #1.A.9)

Accession Number:P60615
Protein Name:Alpha-bungarotoxin isoform A31
Length:95
Molecular Weight:10285.00
Species:Bungarus multicinctus (Many-banded krait) [8616]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate ions, small molecules

Cross database links:

Pfam: PF00087   

Gene Ontology

GO:0005576 C:extracellular region
GO:0045211 C:postsynaptic membrane
GO:0030550 F:acetylcholine receptor inhibitor activity
GO:0009405 P:pathogenesis
GO:0007268 P:synaptic transmission

References (21)

[1] “Genetic characterization of the mRNAs encoding alpha-bungarotoxin: isoforms and RNA editing in Bungarus multicinctus gland cells.”  Liu L.-F.et.al.   9837992
[2] “Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs.”  Chang L.-S.et.al.   10497260
[3] “Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus.”  Mebs D.et.al.   5027709
[4] “Primary structure of alpha-bungarotoxin. Six amino acid residues differ from the previously reported sequence.”  Ohta M.et.al.   3653402
[5] “Isolation of antigenically reactive peptide fragments and localization of antigenic regions of alpha-bungarotoxin.”  Chuang L.Y.et.al.   2458724
[6] “Structural studies of alpha-bungarotoxin. 3. Corrections in the primary sequence and X-ray structure and characterization of an isotoxic alpha-bungarotoxin.”  Kosen P.A.et.al.   3401449
[7] “Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor.”  Servent D.et.al.   9305882
[8] “cDNA sequence analysis and expression of alpha-bungarotoxin from Taiwan banded krait (Bungarus multicinctus).”  Kuo K.-W.et.al.   7488184
[9] “Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo.”  Dajas-Bailador F.et.al.   9840221
[10] “Neutralizing monoclonal antibody specific for alpha-bungarotoxin: preparation and characterization of the antibody, and localization of antigenic region of alpha-bungarotoxin.”  Kase R.et.al.   2476330
[11] “The crystal structure of alpha-bungarotoxin at 2.5-A resolution: relation to solution structure and binding to acetylcholine receptor.”  Love R.A.et.al.   3507686
[12] “Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments.”  Basus V.J.et.al.   3401447
[13] “Structural studies of alpha-bungarotoxin. 2. 1H NMR assignments via an improved relayed coherence transfer nuclear overhauser enhancement experiment.”  Basus V.J.et.al.   3401448
[14] “NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex.”  Basus V.J.et.al.   8241115
[15] “Three-dimensional solution structure of the complex of alpha-bungarotoxin with a library-derived peptide.”  Scherf T.et.al.   9177168
[16] “The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.”  Zeng H.et.al.   11312275
[17] “The binding site of acetylcholine receptor as visualized in the X-ray structure of a complex between alpha-bungarotoxin and a mimotope peptide.”  Harel M.et.al.   11683996
[18] “A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.”  Scherf T.et.al.   11381118
[19] “NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor.”  Scarselli M.et.al.   11814338
[20] “NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.”  Moise L.et.al.   11790782
[21] “The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR.”  Samson A.O.et.al.   12160749
Structure:
1ABT   1BXP   1HAA   1HAJ   1HC9   1HOY   1IDG   1IDH   1IDI   1IDL   [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTLLLTLVV VTIVCLDLGY TIVCHTTATS PISAVTCPPG ENLCYRKMWC DAFCSSRGKV 
61:	VELGCAATCP SKKPYEEVTC CSTDKCNPHP KQRPG