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1.C.75.1.1
The Serratia pore-forming hemolysin/toxin of 1608 aas, ShlA. ShlA expression allows Serratia to trigger a Ca2+ signal that reshapes cytoskeleton dynamics and ends up pushing the Serratia-containing vacuoles out of the cell in an exocytic-like process (Di Venanzio et al. 2016). Thus, pore-forming toxins can allow bacteria to exit without compromising host cell integrity. ShlA triggers cadherin cleavage by promoting calcium influx which activates ADAM10 for proteolysis (Reboud et al. 2017).

Accession Number:P15320
Protein Name:ShlA
Length:1608
Molecular Weight:165079.00
Species:Serratia marcescens [615]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate small molecules

Cross database links:

Pfam: PF05860   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0009405 P:pathogenesis

References (1)

[1] “Molecular characterization of the hemolysin determinant of Serratia marcescens.”  Poole K.et.al.   3290200

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKNNNFRLSA AGKLAAALAI ILAASAGAYA AEIVAANGAN GPGVSTAATG AQVVDIVAPN 
61:	GNGLSHNQYQ DFNVNQPGAV LNNSREAGLS QLAGQLGANP NLGGREASVI LNEVIGRNPS 
121:	LLHGQQEIFG MAADYVLANP NGISCQSCGF INTSHSSLVV GNPLVENGVL QGYSTFGNRN 
181:	TLSLNGTLNA GGVLDLIAPK IDSRGEVIVQ DFKQSNGKVT SAAINAISGL NRVARDGTVQ 
241:	ASQQMPTALD SYYLGSMQAG RINIINTAQG SGVKLAGSLN AGDELKVKAY DIRSESRVDD 
301:	ASSNKNGGDN YQNYRGGIYV NDRSSSQTLT RTELKGKNIS LVADNHAHLT ATDIRGEDIT 
361:	LQGGKLTLDG QQLKQTQGHT DDRWFYSWQY DVTREREQLQ QAGSTVAASG SAKLISTQED 
421:	VKLLGANVSA DRALSVKAAR DVHLAGLVEK DKSSERGYQR NHTSSLRTGR WSNSDESESL 
481:	KASELRSEGE LTLKAGRNVS TQGAKVHAQR DLTIDADNQI QVGVQKTANA KAVRDDKTSW 
541:	GGIGGGDNKN NSNRREISHA SELTSGGTLR LNGQQGVTIT GSKARGQKGG EVTATHGGLR 
601:	IDNALSTTVD KIDARTGTAF NITSSSHKAD NSYQSSTASE LKSDTNLTLV SHKDADVIGS 
661:	QVASGGELSV ESKTGNINVK AAERQQNIDE QKTALTVNGY AKEAGDKQYR AGLRIEHTRD 
721:	SEKTTRTENS ASSLSGGSVK LKAEKDVTFS GSKLVADKGD ASVSGNKVSF LAADDKTASN 
781:	TEQTKIGGGF YYTGGIDKLG SGVEAGYENN KTQAQSSKAI TSGSDVKGNL TINARDKLTQ 
841:	QGAQHSVGGA YQENAAGVDH LAAADTASTT TTKTDVGVNI GANVDYSAVT RPVERAVGKA 
901:	AKLDATGVIN DIGGIGAPNV GLDIGAQGGS SEKRSSSSQA VVSSVQAGSI DINAKGEVRD 
961:	QGTQYQASKG AVNLTADSHR SEAAANRQDE QSRDTRGSAG VRVYTTTGSD LTVDAKGEGG 
1021:	TQRSNSSASQ AVTGSIDAAN GINVNVKKDA IYQGTALNGG RGKTAVNAGG DIRLDQASDK 
1081:	QSESRSGFNV KASAKGGFTA DSKNFGAGFG GGTHNGESSS STAQVGNISG QQGVELKAGR 
1141:	DLTLQGTDVK SQGDVSLSAG NKVALQAAES TQTRKESKLS GNIDLGAGSS DSKEKTGGNL 
1201:	SAGGAFDIAK VNESATERQG ATIASDGKVT LSANGKGDDA LHLQGAKVSG GSAALEAKNG 
1261:	GILLESAKNE QHKDNWSLGI KANAKGGQTF NKDAGGKVDP NTGKDTHTLG AGLKVGVEQQ 
1321:	DKTTHANTGI TAGDVTLNSG KDTRLAGARV DADSVQGKVG GDLHVESRKD VENGVKVDVD 
1381:	AGLSHSNDPG SSITSKLSKV GTPRYAGKVK EKLEAGVNKV ADATTDKYNS VARRLDPQQD 
1441:	TTGAVSFSKA EGKVTLPATP AGEKPQGPLW DRGARTVGGA VKDSITGPAG RQGHLKVNAD 
1501:	VVNNNAVGEQ SAIAGKNGVA LQVGGQTQLT GGEIRSQQGK VELGGSQVSQ QDVNGQRYQG 
1561:	GGRVDAAATV GGLLGGAAKQ SVAGNVPFAS GHASTQQADA KAGVFSGK