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Histatin 3 precursor

Accession Number:P15516
Protein Name:Histatin-3
Molecular Weight:6149.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate ATP

Cross database links:

Genevestigator: P15516
RefSeq: NP_000191.1   
Entrez Gene ID: 3347   
OMIM: 142702  gene
KEGG: hsa:3347   

Gene Ontology

GO:0005576 C:extracellular region
GO:0046872 F:metal ion binding
GO:0005515 F:protein binding
GO:0031214 P:biomineral formation
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0031640 P:killing of cells of another organism

References (15)

[1] “Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).”  Sabatini   2719677
[2] “Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.”  Dickinson   3426601
[3] “Molecular cloning of human submandibular histatins.”  Vanderspek   2344289
[4] “Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.”  Chen   8336540
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project   15489334
[6] “Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant.”  Sabatini   7951254
[7] “Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.”  Oppenheim   3286634
[8] “Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.”  Sugiyama   2372245
[9] “A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway.”  Castagnola   15272024
[10] “Candidacidal activity of recombinant human salivary histatin-5 and variants.”  Tsai   8945538
[11] “Zinc and copper bind to unique sites of histatin 5.”  Grogan   11226423
[12] “Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease.”  Gusman   11179305
[13] “Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5.”  Li   12761219
[14] “Immunocytochemical localization of histatins in human salivary glands.”  Ahmad   14966203
[15] “Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.”  Cabras   17503797

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