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1.C.8.1.2
Tetanus neurotoxin

Accession Number:P04958
Protein Name:TETX aka CTP60
Length:1315
Molecular Weight:150682.00
Species:Clostridium tetani [1513]
Location1 / Topology2 / Orientation3: Secreted1 / Multi-pass membrane protein2
Substrate peptides

Cross database links:

HEGENOM: HBG419785
RefSeq: NP_783831.1   
Entrez Gene ID: 1061100   
Pfam: PF01742    PF07951    PF07953    PF07952   
Drugbank: Drugbank Link   
KEGG: ctc:pE88_60   

Gene Ontology

GO:0005576 C:extracellular region
GO:0004222 F:metalloendopeptidase activity
GO:0050827 F:toxin receptor binding
GO:0008270 F:zinc ion binding
GO:0051609 P:inhibition of neurotransmitter uptake
GO:0009405 P:pathogenesis
GO:0006508 P:proteolysis

References (9)

[1] “Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins.”  Eisel U.et.al.   3536478
[2] “The complete nucleotide sequence of tetanus toxin.”  Fairweather N.F.et.al.   3774547
[3] “The genome sequence of Clostridium tetani, the causative agent of tetanus disease.”  Brueggemann H.et.al.   12552129
[4] “Cloning, nucleotide sequencing, and expression of tetanus toxin fragment C in Escherichia coli.”  Fairweather N.F.et.al.   3510187
[5] “Arrangement of disulfide bridges and positions of sulfhydryl groups in tetanus toxin.”  Krieglstein K.et.al.   2108021
[6] “Limited proteolysis of tetanus toxin. Relation to activity and identification of cleavage sites.”  Krieglstein K.G.et.al.   1935979
[7] “Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.”  Schiavo G.et.al.   1396558
[8] “Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin.”  Schiavo G.et.al.   1331807
[9] “Structure of the receptor binding fragment HC of tetanus neurotoxin.”  Umland T.C.et.al.   9334741
Structure:
1A8D   1AF9   1D0H   1DFQ   1DIW   1DLL   1FV2   1FV3   1YVG   1YXW   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPITINNFRY SDPVNNDTII MMEPPYCKGL DIYYKAFKIT DRIWIVPERY EFGTKPEDFN 
61:	PPSSLIEGAS EYYDPNYLRT DSDKDRFLQT MVKLFNRIKN NVAGEALLDK IINAIPYLGN 
121:	SYSLLDKFDT NSNSVSFNLL EQDPSGATTK SAMLTNLIIF GPGPVLNKNE VRGIVLRVDN 
181:	KNYFPCRDGF GSIMQMAFCP EYVPTFDNVI ENITSLTIGK SKYFQDPALL LMHELIHVLH 
241:	GLYGMQVSSH EIIPSKQEIY MQHTYPISAE ELFTFGGQDA NLISIDIKND LYEKTLNDYK 
301:	AIANKLSQVT SCNDPNIDID SYKQIYQQKY QFDKDSNGQY IVNEDKFQIL YNSIMYGFTE 
361:	IELGKKFNIK TRLSYFSMNH DPVKIPNLLD DTIYNDTEGF NIESKDLKSE YKGQNMRVNT 
421:	NAFRNVDGSG LVSKLIGLCK KIIPPTNIRE NLYNRTASLT DLGGELCIKI KNEDLTFIAE 
481:	KNSFSEEPFQ DEIVSYNTKN KPLNFNYSLD KIIVDYNLQS KITLPNDRTT PVTKGIPYAP 
541:	EYKSNAASTI EIHNIDDNTI YQYLYAQKSP TTLQRITMTN SVDDALINST KIYSYFPSVI 
601:	SKVNQGAQGI LFLQWVRDII DDFTNESSQK TTIDKISDVS TIVPYIGPAL NIVKQGYEGN 
661:	FIGALETTGV VLLLEYIPEI TLPVIAALSI AESSTQKEKI IKTIDNFLEK RYEKWIEVYK 
721:	LVKAKWLGTV NTQFQKRSYQ MYRSLEYQVD AIKKIIDYEY KIYSGPDKEQ IADEINNLKN 
781:	KLEEKANKAM ININIFMRES SRSFLVNQMI NEAKKQLLEF DTQSKNILMQ YIKANSKFIG 
841:	ITELKKLESK INKVFSTPIP FSYSKNLDCW VDNEEDIDVI LKKSTILNLD INNDIISDIS 
901:	GFNSSVITYP DAQLVPGING KAIHLVNNES SEVIVHKAMD IEYNDMFNNF TVSFWLRVPK 
961:	VSASHLEQYG TNEYSIISSM KKHSLSIGSG WSVSLKGNNL IWTLKDSAGE VRQITFRDLP 
1021:	DKFNAYLANK WVFITITNDR LSSANLYING VLMGSAEITG LGAIREDNNI TLKLDRCNNN 
1081:	NQYVSIDKFR IFCKALNPKE IEKLYTSYLS ITFLRDFWGN PLRYDTEYYL IPVASSSKDV 
1141:	QLKNITDYMY LTNAPSYTNG KLNIYYRRLY NGLKFIIKRY TPNNEIDSFV KSGDFIKLYV 
1201:	SYNNNEHIVG YPKDGNAFNN LDRILRVGYN APGIPLYKKM EAVKLRDLKT YSVQLKLYDD 
1261:	KNASLGLVGT HNGQIGNDPN RDILIASNWY FNHLKDKILG CDWYFVPTDE GWTND