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1.C.84.1.1
Leakage-promoting cyclic peptide, Subtilosin (43aas)

Accession Number:O07623
Protein Name:Subtilosin
Length:43
Molecular Weight:4325.00
Species:Bacillus subtilis [1423]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

RefSeq: NP_391616.1   
Entrez Gene ID: 938512   
Pfam: PF11420   
KEGG: bsu:BSU37350   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005102 F:receptor binding
GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium

References (6)

[1] “The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).”  Presecan E.et.al.   9353933
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Subtilosin A, a new antibiotic peptide produced by Bacillus subtilis 168: isolation, structural analysis, and biogenesis.”  Babasaki K.et.al.   3936839
[4] “Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin.”  Zheng G.et.al.   10572140
[5] “Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis.”  Nakano M.M.et.al.   10809710
[6] “Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine.”  Kawulka K.et.al.   12696888
Structure:
1PXQ     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKAVIVENK GCATCSIGAA CLVDGPIPDF EIAGATGLFG LWG