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1.C.85.1.1
β-defensin-1

Accession Number:P60022
Protein Name:β-defensin-1
Length:68
Molecular Weight:7420.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P60022
HEGENOM: HBG127033
RefSeq: NP_005209.1   
Entrez Gene ID: 1672   
Pfam: PF00711   
OMIM: 602056  gene
KEGG: hsa:1672   

Gene Ontology

GO:0005576 C:extracellular region
GO:0006935 P:chemotaxis
GO:0042742 P:defense response to bacterium
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0045087 P:innate immune response

References (7)

[1] “The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.”  Liu L.et.al.   9268634
[2] “Human airway epithelia express a beta-defensin.”  McCray P.B. Jr.et.al.   9070620
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “hBD-1: a novel beta-defensin from human plasma.”  Bensch K.W.et.al.   7628632
[5] “Chemical synthesis of beta-defensins and LEAP-1/hepcidin.”  Kluever E.et.al.   12010514
[6] “The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.”  Hoover D.M.et.al.   11486002
[7] “Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.”  Bauer F.et.al.   11714914
Structure:
1E4S   1IJU   1IJV   1KJ5   2NLB   2NLC   2NLD   2NLE   2NLF   2NLG   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY 
61:	RGKAKCCK