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1.C.85.1.2
β-defensin-2

Accession Number:O15263
Protein Name:β-defensin 2
Length:64
Molecular Weight:7038.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: O15263
eggNOG: prNOG21780
RefSeq: NP_004933.1    XP_002342852.1   
Entrez Gene ID: 100289462    1673   
Pfam: PF00711   
OMIM: 602215  gene
KEGG: hsa:100289462    hsa:1673   

Gene Ontology

GO:0005576 C:extracellular region
GO:0006935 P:chemotaxis
GO:0042742 P:defense response to bacterium
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0006955 P:immune response

References (8)

[1] “A peptide antibiotic from human skin.”  Harder J.et.al.   9202117
[2] “Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.”  Liu L.et.al.   9831658
[3] “Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells.”  Diamond G.et.al.   10603376
[4] “Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia.”  Harder J.et.al.   10837369
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Chemical synthesis of beta-defensins and LEAP-1/hepcidin.”  Kluever E.et.al.   12010514
[7] “The structure of human beta-defensin-2 shows evidence of higher order oligomerization.”  Hoover D.M.et.al.   10906336
[8] “Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity.”  Bauer F.et.al.   11714914
Structure:
1E4Q   1FD3   1FD4   1FQQ     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRVLYLLFSF LFIFLMPLPG VFGGIGDPVT CLKSGAICHP VFCPRRYKQI GTCGLPGTKC 
61:	CKKP