TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.C.85.2.2
Crotamine-IV-2 toxin of 42 aas and 0 TMSs. Croamines are cationic peptides that possess multiple functions. hey act as cell-penetrating peptides (CPPs), as potent voltage-gated potassium channel inhibitors and as antimicrobial agents (Hayashi et al. 2008). As an antimicrobial peptide, crotamine shows antibacterial activity against E.coli and B.subtilis, and antifungal activity against Candida spp., Trichosporon spp. and C. neoformans. It kills bacteria through membrane permeabilization (Hayashi et al. 2008). It selectively inhibits Kv1.1/KCNA1, Kv1.2/KCNA2 and Kv1.3/KCNA3 channels (Peigneur et al. 2012). It is also hemolytic (Oguiura et al. 2011).

Accession Number:P86193
Protein Name:Crotamine-IV-2
Length:42
Molecular Weight:4907.00
Species:Crotalus durissus cumanensis (South American rattlesnake) [184542]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	YKRCHIKGGH CFPKEKLICI PPSSDIGKMD CPWKRKCCKK RS