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1.C.89.1.1
β-neoendorphin-dynorphin precursor (Proenkephalin B; Preprodynorphin)

Accession Number:P01213
Protein Name:Dynorphin
Length:254
Molecular Weight:28385.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate Ca2+

Cross database links:

Genevestigator: P01213
eggNOG: prNOG18975
HEGENOM: HBG716475
RefSeq: NP_077722.1   
Entrez Gene ID: 5173   
Pfam: PF01160   
OMIM: 131340  gene
KEGG: hsa:5173   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005886 C:plasma membrane
GO:0001515 F:opioid peptide activity
GO:0007218 P:neuropeptide signaling pathway
GO:0007268 P:synaptic transmission

References (7)

[1] “Isolation and structural organization of the human preproenkephalin B gene.”  Horikawa S.et.al.   6316163
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “NMR and structural model of dynorphin A (1-17) bound to dodecylphosphocholine micelles.”  Tessmer M.R.et.al.   9047294
[6] “Dynorphin peptides differentially regulate the human kappa opioid receptor.”  Chen Y.et.al.   17316701
[7] “Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor.”  Merg F.et.al.   16515546
Structure:
2N2F     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAWQGLVLAA CLLMFPSTTA DCLSRCSLCA VKTQDGPKPI NPLICSLQCQ AALLPSEEWE 
61:	RCQSFLSFFT PSTLGLNDKE DLGSKSVGEG PYSELAKLSG SFLKELEKSK FLPSISTKEN 
121:	TLSKSLEEKL RGLSDGFREG AESELMRDAQ LNDGAMETGT LYLAEEDPKE QVKRYGGFLR 
181:	KYPKRSSEVA GEGDGDSMGH EDLYKRYGGF LRRIRPKLKW DNQKRYGGFL RRQFKVVTRS 
241:	QEDPNAYSGE LFDA