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1.C.89.1.2
Proenkephalin A (264aa precursor of opioid peptides)

Accession Number:P01210
Protein Name:Proenkephalin A
Length:267
Molecular Weight:30787.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate Ca2+

Cross database links:

Genevestigator: P01210
eggNOG: prNOG18673
HEGENOM: HBG716475
RefSeq: NP_001129162.1    NP_006202.1   
Entrez Gene ID: 5179   
Pfam: PF01160   
OMIM: 131330  gene
KEGG: hsa:5179   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005184 F:neuropeptide hormone activity
GO:0001515 F:opioid peptide activity
GO:0007218 P:neuropeptide signaling pathway
GO:0007165 P:signal transduction

References (5)

[1] “Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA.”  Comb M.et.al.   7057924
[2] “Isolation and structural organization of the human preproenkephalin gene.”  Noda M.et.al.   6281660
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bonds.”  Lecchi P.et.al.   9126357
Structure:
1PLW   1PLX   2LWC     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM ECEGKLPSLK 
61:	IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY GGFMKRYGGF MKKMDELYPM 
121:	EPEEEANGSE ILAKRYGGFM KKDAEEDDSL ANSSDLLKEL LETGDNRERS HHQDGSDNEE 
181:	EVSKRYGGFM RGLKRSPQLE DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA 
241:	LPSDEEGESY SKEVPEMEKR YGGFMRF