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1.C.92.1.2
Serum amyloid P component precursor, SAP (223aas)

Accession Number:P02743
Protein Name:SAP
Length:223
Molecular Weight:25387.00
Species:Homo sapiens [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

Genevestigator: P02743
eggNOG: prNOG11978
HEGENOM: HBG716040
RefSeq: NP_001630.1   
Entrez Gene ID: 325   
Pfam: PF00354   
Drugbank: Drugbank Link   
OMIM: 104770  gene
KEGG: hsa:325   

Gene Ontology

GO:0005615 C:extracellular space
GO:0046872 F:metal ion binding
GO:0005529 F:sugar binding
GO:0051082 F:unfolded protein binding
GO:0006953 P:acute-phase response
GO:0051131 P:chaperone-mediated protein complex assembly
GO:0006457 P:protein folding

References (14)

[1] “Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1.”  Mantzouranis E.C.et.al.   2987268
[2] “Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component.”  Ohnishi S.et.al.   3029048
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis.”  Prelli F.et.al.   4055725
[6] “Human plasma P component: isolation and characterization.”  Thompson A.R.et.al.   81686
[7] “Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.”  Pepys M.B.et.al.   8202534
[8] “Proteomic characterization of novel serum amyloid P component variants from human plasma and urine.”  Kiernan U.A.et.al.   15174148
[9] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”  Liu T.et.al.   16335952
[10] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.”  Gauci S.et.al.   19413330
[11] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[12] “Structure of pentameric human serum amyloid P component.”  Emsley J.et.al.   8114934
[13] “Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP.”  Hohenester E.et.al.   9217261
[14] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
Structure:
1GYK   1LGN   1SAC   2A3W   2A3X   2A3Y   2W08   3D5O   3KQR   4AVS   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNKPLLWISV LTSLLEAFAH TDLSGKVFVF PRESVTDHVN LITPLEKPLQ NFTLCFRAYS 
61:	DLSRAYSLFS YNTQGRDNEL LVYKERVGEY SLYIGRHKVT SKVIEKFPAP VHICVSWESS 
121:	SGIAEFWING TPLVKKGLRQ GYFVEAQPKI VLGQEQDSYG GKFDRSQSFV GEIGDLYMWD 
181:	SVLPPENILS AYQGTPLPAN ILDWQALNYE IRGYVIIKPL VWV