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1.C.95.1.1
Pore-forming ESAT-6 (ESXA) (95 aas)

Accession Number:P0A564
Protein Name:Rv3875 (esat-6)
Length:95
Molecular Weight:9904.00
Species:Mycobacterium tuberculosis [1773]
Location1 / Topology2 / Orientation3: Secreted1
Substrate small molecules

Cross database links:

HEGENOM: HBG569144
RefSeq: NP_338543.1    YP_178023.1   
Entrez Gene ID: 886209    922546   
KEGG: mtc:MT3989    mtu:Rv3875   

Gene Ontology

GO:0005576 C:extracellular region
GO:0005515 F:protein binding

References (10)

[1] “Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice.”  Andersen P.et.al.   7897219
[2] “Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.”  Soerensen A.L.et.al.   7729876
[3] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[4] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[5] “A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10).”  Berthet F.-X.et.al.   9846755
[6] “Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence.”  Renshaw P.S.et.al.   11940590
[7] “Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.”  Stanley S.A.et.al.   14557536
[8] “Mutually dependent secretion of proteins required for mycobacterial virulence.”  Fortune S.M.et.al.   16030141
[9] “Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.”  Brodin P.et.al.   16368961
[10] “ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.”  DiGiuseppe Champion P.A.et.al.   19682254
Structure:
1WA8   3FAV     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEQQWNFAG IEAAASAIQG NVTSIHSLLD EGKQSLTKLA AAWGGSGSEA YQGVQQKWDA 
61:	TATELNNALQ NLARTISEAG QAMASTEGNV TGMFA